6-Bromo-2,3-dichlorobenzaldehyde

Base Information

• Chemical Name: 6-Bromo-2,3-dichlorobenzaldehyde
• CAS No.: 945999-86-0
• Molecular Formula: C7H3BrCl2O
• Molecular Weight: 253.91
• Mol file: 945999-86-0.mol

Synonyms:6-Bromo-2,3-dichlorobenzaldehyde

Chemical Property of 6-Bromo-2,3-dichlorobenzaldehyde

Chemical Property:

• Boiling Point: 285.7±35.0 °C (760 mmHg)
• PSA: 17.07000
• Density: 1.798±0.06 g/cm3 (20 °C, 760 mmHg)
• LogP: 3.56840

Purity/Quality:

90% ^*data from raw suppliers

6-Bromo-2,3-dichlorobenzaldehyde 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-Bromo-2,3-dichlorobenzaldehyde

There total 2 articles about 6-Bromo-2,3-dichlorobenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2,3-dichlorobenzylaldehyde (6334-18-5) → 6-bromo-2,3-dichlorobenzaldehyde (945999-86-0)

Guidance literature:

With N-Bromosuccinimide; 4-chloro-2-(trifluoromethyl)aniline; palladium diacetate; In 1,2-dichloro-ethane; trifluoroacetic acid; at 60 ℃; for 24h;

DOI:10.1016/j.tetlet.2019.151263

Reference yield: 82.0%

4-bromo-1,2-dichlorobenzene (18282-59-2) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 6-bromo-2,3-dichlorobenzaldehyde (945999-86-0)

Guidance literature:

4-bromo-1,2-dichlorobenzene; With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexanes; at -78 ℃; for 1h;

N,N-dimethyl-formamide; In tetrahydrofuran; hexanes; at -78 - 20 ℃;

upstream raw materials:

4-bromo-1,2-dichlorobenzene

N,N-dimethyl-formamide

2,3-dichlorobenzylaldehyde

Refernces

• 1、 -. "Secondary Amines as Renin Inhibitors". Page/Page column 13. . Retrieved 2009/07/18.