HO-PEG10-tBu

Base Information

• Chemical Name: HO-PEG10-tBu
• CAS No.: 778596-26-2
• Molecular Formula: C27H54O13
• Molecular Weight: 586.70986
• Mol file: 778596-26-2.mol

Synonyms:HO-PEG10-tBu;33-Hydroxy-4,7,10,13,16,19,22,25,28,31-decaoxatritriacontanoic acid 1,1-dimethylethyl ester;HO-PEG10-CH2CH2COOtBu;PEG11-t-butly ester;HO-PEG10-CH2CH2COOtBu;Hydroxy-PEG10-t-butly ester;Hydroxy-PEG10-t-butyl ester

Chemical Property of HO-PEG10-tBu

Chemical Property:

• PSA: 138.83000
• LogP: 0.87650
• Solubility.: Soluble in Water, DMSO, DMF, DCM

Purity/Quality:

97% ^*data from raw suppliers

HO-PEG10-CH2CH2COOtBu min.97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: Hydroxy-PEG10-t-butyl ester is a PEG linker containing a hydroxyl group with a t-butyl ester. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The t-butyl protected carboxyl group can be deprotected under acidic conditions.

Technology Process of HO-PEG10-tBu

There total 7 articles about HO-PEG10-tBu which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

3-(2-{2-[2-(2-{2-[2-(2-{2-[2-(2-trityloxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-ethoxy)-propionic acid tert-butyl ester (778596-25-1) → tert-butyl 1-hydroxy-3,6,9,12,15,18,21,24,27,30-decaoxatritriacontan-33-oate (778596-26-2)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; under 1448.01 Torr;

DOI:10.1021/jm049705s

Reference yield:

Tetraethylene glycol (112-60-7) → tert-butyl 1-hydroxy-3,6,9,12,15,18,21,24,27,30-decaoxatritriacontan-33-oate (778596-26-2)

Guidance literature:

Multi-step reaction with 4 steps

1.1: Na / tetrahydrofuran

1.2: 78 percent / tetrahydrofuran / 20 h / 20 °C

2.1: 80 percent / Et₃N / acetonitrile / 5 h / 20 °C

3.1: t-BuOK / toluene / 1 h

3.2: 67 percent / toluene

4.1: 77 percent / H₂ / Pd/C / methanol / 20 °C / 1448.01 Torr

With potassium tert-butylate; hydrogen; sodium; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; toluene; acetonitrile;

DOI:10.1021/jm049705s

Reference yield:

pentaethylene glycol (2615-15-8) → tert-butyl 1-hydroxy-3,6,9,12,15,18,21,24,27,30-decaoxatritriacontan-33-oate (778596-26-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 74 percent / pyridine / 20 °C

2.1: t-BuOK / toluene / 1 h

2.2: 67 percent / toluene

3.1: 77 percent / H₂ / Pd/C / methanol / 20 °C / 1448.01 Torr

With pyridine; potassium tert-butylate; hydrogen; palladium on activated charcoal; In methanol; toluene;

DOI:10.1021/jm049705s

upstream raw materials:

3-(2-{2-[2-(2-{2-[2-(2-{2-[2-(2-trityloxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-ethoxy)-propionic acid tert-butyl ester

Tetraethylene glycol

pentaethylene glycol

tert-Butyl acrylate

Downstream raw materials:

34-(p-toluenesulfonyl)-4,7,10,13,16,19,22,25,28,31,34-undecaoxatetracontanoic acid tert-butyl ester

3-(2-{2-[2-(2-{2-[2-(2-{2-[2-(2-mercapto-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-ethoxy)-propionic acid tert-butyl ester

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