3-AMino-5-broMo-2-hydroxyMethylpyridine

Base Information

• Chemical Name: 3-AMino-5-broMo-2-hydroxyMethylpyridine
• CAS No.: 1363381-68-3
• Molecular Weight: 203.04
• Mol file: 1363381-68-3.mol

Synonyms:2-Pyridinemethanol, 3-amino-5-bromo-;(3-amino-5-bromopyridin-2-yl)methanol;3-AMino-5-broMo-2-hydroxyMethylpyridine

Chemical Property of 3-AMino-5-broMo-2-hydroxyMethylpyridine

Chemical Property:

• Boiling Point: 374.4±37.0 °C(Predicted)
• PKA: 12.95±0.10(Predicted)
• Density: 1.766±0.06 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

(3-amino-5-bromopyridin-2-yl)methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 3-AMino-5-broMo-2-hydroxyMethylpyridine

There total 3 articles about 3-AMino-5-broMo-2-hydroxyMethylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

3-amino-5-bromo-pyridine-2-carboxylic acid methyl ester (1072448-08-8) → (3-amino-5-bromopyridin-2-yl)methanol (1363381-68-3)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 1h; Inert atmosphere;

DOI:10.3390/molecules26216648

Reference yield:

C6H5BrN2O3 → (3-amino-5-bromopyridin-2-yl)methanol (1363381-68-3)

Guidance literature:

With ammonium chloride; zinc; In methanol; dichloromethane; at 75 ℃; for 4h; Inert atmosphere;

DOI:10.1021/acsmedchemlett.0c00239

Reference yield:

3-amino-5-bromo-pyridine-2-carboxylic acid (870997-85-6) → (3-amino-5-bromopyridin-2-yl)methanol (1363381-68-3)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / water; 1,4-dioxane / 18 h / Reflux; Inert atmosphere

2: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; lithium aluminium tetrahydride; In tetrahydrofuran; 1,4-dioxane; water;

DOI:10.3390/molecules26216648

upstream raw materials:

3-amino-5-bromo-pyridine-2-carboxylic acid methyl ester

3-amino-5-bromo-pyridine-2-carboxylic acid

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