Methyl 3-amino-5-bromopicolinate

Base Information

• Chemical Name: Methyl 3-amino-5-bromopicolinate
• CAS No.: 1072448-08-8
• Molecular Formula: C7H7BrN2O2
• Molecular Weight: 231.049
• Hs Code.: 2933399090
• Mol file: 1072448-08-8.mol

Synonyms:Methyl 3-amino-5-bromopicolinate;3-AMino-5-broMopyridin-2-carboxylic acid Methyl ester;Methyl 3-aMino-5-broMopyridine-2-carboxylate

Chemical Property of Methyl 3-amino-5-bromopicolinate

Chemical Property:

• Boiling Point: 371.9±37.0 °C(Predicted)
• PKA: 0.30±0.10(Predicted)
• PSA: 65.21000
• Density: 1.662±0.06 g/cm3(Predicted)
• LogP: 1.79410

Purity/Quality:

98%,99%, ^*data from raw suppliers

Methyl3-amino-5-bromopicolinate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 3-amino-5-bromopicolinate

There total 4 articles about Methyl 3-amino-5-bromopicolinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

3-amino-5-bromo-pyridine-2-carboxylic acid (870997-85-6) + methyl iodide (74-88-4) → 3-amino-5-bromo-pyridine-2-carboxylic acid methyl ester (1072448-08-8)

Guidance literature:

With potassium carbonate; In N,N-dimethyl acetamide; at 25 ℃; for 12h; Inert atmosphere;

Reference yield: 80.0%

methanol (67-56-1) + 3-amino-5-bromo-pyridine-2-carboxylic acid (870997-85-6) → 3-amino-5-bromo-pyridine-2-carboxylic acid methyl ester (1072448-08-8)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; water; for 18h; Reflux; Inert atmosphere;

DOI:10.3390/molecules26216648

Reference yield:

methyl 5-bromo-3-[(4-methoxyphenyl)methylamino]pyridine-2-carboxylate → 3-amino-5-bromo-pyridine-2-carboxylic acid methyl ester (1072448-08-8)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 40 ℃; for 18h;

upstream raw materials:

3-amino-5-bromo-pyridine-2-carboxylic acid

methyl iodide

methyl 5-bromo-3-fluoro-pyridine-2-carboxylate

methanol

Refernces

• 1、 Bataille, Carole J. R.,Cogswell, Thomas J.,Davies, Stephen G.,Georgiou, Irene,Jackson, Thomas R.,Jay-Smith, Morgan,Josa-Culleré, Laia,Milne, Thomas A.,Russell, Angela J.,Vyas, Paresh,Wynne, Graham M.. "Identification and preliminary structure-activity relationship studies of 1,5-dihydrobenzo[e][1,4]oxazepin-2(3h)-ones that induce differentiation of acute myeloid leukemia cells in vitro". . . Retrieved 2021/11/11.