N-(2-Chloro-6-(hydroxymethyl)phenyl)-2-((6-(4-(2-hydroxyethyl)-1-piperazinyl)-2-methyl-4-pyrimidinyl)amino)-5-thiazolecarboxamide

Base Information

Chemical Name:N-(2-Chloro-6-(hydroxymethyl)phenyl)-2-((6-(4-(2-hydroxyethyl)-1-piperazinyl)-2-methyl-4-pyrimidinyl)amino)-5-thiazolecarboxamide
CAS No.:910297-58-4
Molecular Formula:C₂₂H₂₆ClN₇O₃S
Molecular Weight:504.013
Hs Code.:
UNII:O4S6Z9X0XS
DSSTox Substance ID:DTXSID90474433
Wikidata:Q27285325
Mol file:910297-58-4.mol

Synonyms:Hydroxymethyl Dasatinib;910297-58-4;Dasatinib metabolite M24;N-(2-Chloro-6-(hydroxymethyl)phenyl)-2-((6-(4-(2-hydroxyethyl)-1-piperazinyl)-2-methyl-4-pyrimidinyl)amino)-5-thiazolecarboxamide;BMS-749426;O4S6Z9X0XS;N-[2-chloro-6-(hydroxymethyl)phenyl]-2-[[6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl]amino]-1,3-thiazole-5-carboxamide;5-Thiazolecarboxamide, N-(2-chloro-6-(hydroxymethyl)phenyl)-2-((6-(4-(2-hydroxyethyl)-1-piperazinyl)-2-methyl-4-pyrimidinyl)amino)-;N-(2-Chloro-6-(hydroxymethyl)phenyl)-2-((6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methyl-pyrimidin-4-yl)amino)thiazole-5-carboxamide;UNII-O4S6Z9X0XS;SCHEMBL1705125;DTXSID90474433;KZNOWBHQESWSTD-UHFFFAOYSA-N;AKOS030255280;HY-W700620;CS-0809149;FT-0669779;Q27285325;n-(2-chloro-6-(hydroxymethyl)phenyl)-2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide

Suppliers and Price of N-(2-Chloro-6-(hydroxymethyl)phenyl)-2-((6-(4-(2-hydroxyethyl)-1-piperazinyl)-2-methyl-4-pyrimidinyl)amino)-5-thiazolecarboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
HydroxymethylDasatinib
5mg
$ 675.00

TRC
HydroxymethylDasatinib
2mg
$ 275.00

TRC
HydroxymethylDasatinib
1mg
$ 150.00

American Custom Chemicals Corporation
HYDROXYMETHYL DASATINIB 95.00%
10MG
$ 1963.50

American Custom Chemicals Corporation
HYDROXYMETHYL DASATINIB 95.00%
1MG
$ 750.75

Total 9 raw suppliers

Chemical Property of N-(2-Chloro-6-(hydroxymethyl)phenyl)-2-((6-(4-(2-hydroxyethyl)-1-piperazinyl)-2-methyl-4-pyrimidinyl)amino)-5-thiazolecarboxamide

Chemical Property:

PKA:10.71±0.70(Predicted)
PSA：154.98000
Density:1.465g/cm³
LogP:2.64630
Storage Temp.:Refrigerator
Solubility.:DMSO (Slightly), Methanol (Slightly)
XLogP3:2.9
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:10
Rotatable Bond Count:8
Exact Mass:503.1506366
Heavy Atom Count:34
Complexity:660

Purity/Quality:

97% ^*data from raw suppliers

HydroxymethylDasatinib ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=NC(=CC(=N1)N2CCN(CC2)CCO)NC3=NC=C(S3)C(=O)NC4=C(C=CC=C4Cl)CO
Uses An oxidative metabolite of Dasatinib (M24 metabolite); used in the treatment of cancers and immune diseases. It is a COVID19-related research product. Hydroxymethyl Dasatinib is an oxidative metabolite of Dasatinib (M24 metabolite); used in the treatment of cancers and immune diseases.

Technology Process of N-(2-Chloro-6-(hydroxymethyl)phenyl)-2-((6-(4-(2-hydroxyethyl)-1-piperazinyl)-2-methyl-4-pyrimidinyl)amino)-5-thiazolecarboxamide

There total 1 articles about N-(2-Chloro-6-(hydroxymethyl)phenyl)-2-((6-(4-(2-hydroxyethyl)-1-piperazinyl)-2-methyl-4-pyrimidinyl)amino)-5-thiazolecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%