8-CHLORO-1,2,3,4-TETRAHYDROCARBAZOLE

Base Information

• Chemical Name: 8-CHLORO-1,2,3,4-TETRAHYDROCARBAZOLE
• CAS No.: 53475-34-6
• Molecular Formula: C12H12ClN
• Molecular Weight: 205.687
• Hs Code.: 2933990090
• Mol file: 53475-34-6.mol

Synonyms:8-CHLORO-1,2,3,4-TETRAHYDROCARBAZOLE

Chemical Property of 8-CHLORO-1,2,3,4-TETRAHYDROCARBAZOLE

Chemical Property:

• PSA: 15.79000
• LogP: 3.70010

Purity/Quality:

99% ^*data from raw suppliers

8-CHLORO-1,2,3,4-TETRAHYDROCARBAZOLE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 8-CHLORO-1,2,3,4-TETRAHYDROCARBAZOLE

There total 12 articles about 8-CHLORO-1,2,3,4-TETRAHYDROCARBAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

o-chlorophenylhydrazine hydrochloride (41052-75-9) + cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) → 8-chloro-2,3,4,9-tetrahydro-1H-carbazole (53475-34-6)

Guidance literature:

With 1,3-bis(3-sulfopropyl)-1H-imidazol-3-ium trifluoromethanesulfonate; In water; at 100 ℃; for 0.333333h; Microwave irradiation; Green chemistry;

DOI:10.1016/j.jfluchem.2012.09.010

Reference yield: 92.0%

cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) + (2-chlorophenyl)hydrazine (10449-07-7) → 8-chloro-2,3,4,9-tetrahydro-1H-carbazole (53475-34-6)

Guidance literature:

With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; In ethyl acetate; at 110 ℃; for 0.166667h; Microwave irradiation; Sealed vessel;

DOI:10.1016/j.tetlet.2011.06.053

Reference yield: 66.0%

o-chlorophenylhydrazine hydrochloride (41052-75-9) + 1-nitrocyclohexane (1122-60-7) → 8-chloro-2,3,4,9-tetrahydro-1H-carbazole (53475-34-6)

Guidance literature:

o-chlorophenylhydrazine hydrochloride; 1-nitrocyclohexane; With sodium methylate; In methanol; at 20 ℃; for 2h;

With sulfuric acid; In methanol; at 90 ℃; for 3h; Further stages.;

DOI:10.1016/j.tetlet.2007.01.031

upstream raw materials:

cyclohexanone-(2-chloro-phenylhydrazone)

acetic acid

o-chloroaniline

cyclohexanone-2-ol

Downstream raw materials:

9H-carbazole

Refernces

• 1、 Zhang, Gang. "Embedding Heteroatoms and Adjacent Pentagons in Concave Molecules". . p. 1957 - 1961. Retrieved 2020.
• 2、 -. "Method for preparing indole compounds through catalysis of ionic liquid". Paragraph 0046-0048. . Retrieved 2018/02/04.