2-aMino-6-broMoquinazolin-4-ol

Base Information

• Chemical Name: 2-aMino-6-broMoquinazolin-4-ol
• CAS No.: 130148-53-7
• Molecular Formula: C₈H₆BrN₃O
• Molecular Weight: 240.059
• Hs Code.: 2933990090
• Mol file: 130148-53-7.mol

Synonyms:2-aMino-6-broMoquinazolin-4-ol;4(3H)-Quinazolinone, 2-amino-6-bromo-;2-amino-6-bromoquinazolin-4(1H)-one;2-Amino-6-bromo-4(1H)-quinazolinone;2-Amino-6-bromo-4-hydroxyquinazoline

Chemical Property of 2-aMino-6-broMoquinazolin-4-ol

Chemical Property:

• Melting Point: >250 °C
• Boiling Point: 425.7±47.0 °C(Predicted)
• PKA: 2.51±0.20(Predicted)
• PSA: 72.76000
• Density: 1.99±0.1 g/cm3(Predicted)
• LogP: 1.61020
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

99%, ^*data from raw suppliers

2-Amino-6-bromoquinazolin-4-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-aMino-6-broMoquinazolin-4-ol

There total 4 articles about 2-aMino-6-broMoquinazolin-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

chloroformamidine hydrochloride (29671-92-9) + 5-Bromo-2-aminobenzoic acid (5794-88-7) → 2-amino-6-bromoquinazolin-4(3H)-one (130148-53-7)

Guidance literature:

With dimethylsulfone; at 140 ℃; for 3h;

DOI:10.1021/acs.jmedchem.1c00179

Reference yield: 40.0%

CYANAMID (420-04-2) + 5-Bromo-2-aminobenzoic acid (5794-88-7) → 2-amino-6-bromoquinazolin-4(3H)-one (130148-53-7)

Guidance literature:

With hydrogenchloride; In ethanol; for 6h; Heating;

DOI:10.1021/jo00002a052

Reference yield:

C8H6BrN3O → 2-amino-6-bromoquinazolin-4(3H)-one (130148-53-7)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; CYANAMID; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; molybdenum hexacarbonyl; In 1,4-dioxane; at 140 ℃; for 0.333333h; Microwave irradiation;

DOI:10.1021/acs.joc.6b00249

upstream raw materials:

CYANAMID

5-Bromo-2-aminobenzoic acid

4-bromo-2-iodoaniline

chloroformamidine hydrochloride

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