(6-Methoxy-5-(trifluoromethyl)pyridin-3-yl)methanol

Base Information

Chemical Name:(6-Methoxy-5-(trifluoromethyl)pyridin-3-yl)methanol
CAS No.:887707-31-5
Molecular Formula:C8H8F3NO2
Molecular Weight:207.15
Hs Code.:
DSSTox Substance ID:DTXSID301238982
Mol file:887707-31-5.mol

Synonyms:(6-Methoxy-5-(trifluoromethyl)pyridin-3-yl)methanol;887707-31-5;[6-methoxy-5-(trifluoromethyl)pyridin-3-yl]methanol;3-Pyridinemethanol, 6-methoxy-5-(trifluoromethyl)-;6-METHOXY-5-(TRIFLUOROMETHYL)-3-PYRIDINEMETHANOL;DTXSID301238982

Suppliers and Price of (6-Methoxy-5-(trifluoromethyl)pyridin-3-yl)methanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
2-METHOXY-3-(TRIFLUOROMETHYL)-5-HYDROXYMETHYLPYRIDINE 95.00%
5MG
$ 500.30

Alichem
2-Methoxy-3-(trifluoromethyl)pyridine-5-methanol
1g
$ 3068.70

Alichem
2-Methoxy-3-(trifluoromethyl)pyridine-5-methanol
500mg
$ 1617.60

Total 2 raw suppliers

Chemical Property of (6-Methoxy-5-(trifluoromethyl)pyridin-3-yl)methanol

Chemical Property:

Melting Point:40-43 °C
Boiling Point:262.3±40.0 °C(Predicted)
PKA:13.10±0.10(Predicted)
PSA：42.35000
Density:1.345±0.06 g/cm3(Predicted)
LogP:1.60130
XLogP3:1.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:2
Exact Mass:207.05071298
Heavy Atom Count:14
Complexity:186

Purity/Quality:

99% ^*data from raw suppliers

2-METHOXY-3-(TRIFLUOROMETHYL)-5-HYDROXYMETHYLPYRIDINE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=C(C=C(C=N1)CO)C(F)(F)F

Technology Process of (6-Methoxy-5-(trifluoromethyl)pyridin-3-yl)methanol

There total 5 articles about (6-Methoxy-5-(trifluoromethyl)pyridin-3-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 887707-29-1
5-cyano-2-methoxy-3-trifluoromethylpyridine

: 887707-31-5
2-methoxy-3-trifluoromethyl-5-pyridinemethanol

Guidance literature:: 5-cyano-2-methoxy-3-trifluoromethylpyridine; With diisobutylaluminium hydride; In toluene; at 20 ℃; for 12h;

With sodium tetrahydroborate; In methanol; at 20 ℃; for 12h;
DOI:10.1080/00397910500516134

Reference yield:

: 22245-83-6
3-(trifluoromethyl)pyridin-2-ol

: 887707-31-5
2-methoxy-3-trifluoromethyl-5-pyridinemethanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate; iodine / H₂O / 13 h / 20 - 50 °C

2.1: 920 mg / silver(I) carbonate / hexane; tetrahydrofuran / 25 h / 40 °C

3.1: 82 percent / tetrakis(triphenylphosphine)palladium⁽⁰⁾ / dimethylformamide / 8 h / 80 °C

4.1: diisobutyl aluminum hydride / toluene / 12 h / 20 °C

4.2: 43 percent / sodium borohydride / methanol / 12 h / 20 °C

With iodine; diisobutylaluminium hydride; potassium carbonate; silver carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; hexane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1080/00397910500516134

Reference yield:

: 887707-27-9
5-iodo-2-methoxy-3-(trifluoromethyl)pyridine

: 887707-31-5
2-methoxy-3-trifluoromethyl-5-pyridinemethanol

Guidance literature:: Multi-step reaction with 2 steps

1.1: 82 percent / tetrakis(triphenylphosphine)palladium⁽⁰⁾ / dimethylformamide / 8 h / 80 °C

2.1: diisobutyl aluminum hydride / toluene / 12 h / 20 °C

2.2: 43 percent / sodium borohydride / methanol / 12 h / 20 °C

With diisobutylaluminium hydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; toluene;
DOI:10.1080/00397910500516134