5-IODO-2-METHOXY-3-(TRIFLUOROMETHYL)-PYRIDINONE

Base Information

• Chemical Name: 5-IODO-2-METHOXY-3-(TRIFLUOROMETHYL)-PYRIDINONE
• CAS No.: 887707-27-9
• Molecular Formula: C7H5F3INO2
• Molecular Weight: 303.02
• Mol file: 887707-27-9.mol

Synonyms:5-IODO-2-METHOXY-3-(TRIFLUOROMETHYL)-PYRIDINONE;5-iodo-2-methoxy-3-(trifluoromethyl)Pyridine

Chemical Property of 5-IODO-2-METHOXY-3-(TRIFLUOROMETHYL)-PYRIDINONE

Chemical Property:

• PSA: 22.12000
• LogP: 2.71360

Purity/Quality:

99%min ^*data from raw suppliers

5-Iodo-2-methoxy-3-(trifluoromethyl)pyridine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-IODO-2-METHOXY-3-(TRIFLUOROMETHYL)-PYRIDINONE

There total 3 articles about 5-IODO-2-METHOXY-3-(TRIFLUOROMETHYL)-PYRIDINONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-hydroxy-3-trifluoromethyl-5-(iodo)pyridine (887707-23-5) + methyl iodide (74-88-4) → 5-iodo-2-methoxy-3-(trifluoromethyl)pyridine (887707-27-9)

Guidance literature:

With silver carbonate; In tetrahydrofuran; hexane; at 40 ℃; for 25h;

DOI:10.1080/00397910500516134

Reference yield:

3-(trifluoromethyl)pyridin-2-ol (22245-83-6) → 5-iodo-2-methoxy-3-(trifluoromethyl)pyridine (887707-27-9)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate; iodine / H₂O / 13 h / 20 - 50 °C

2: 920 mg / silver(I) carbonate / hexane; tetrahydrofuran / 25 h / 40 °C

With iodine; potassium carbonate; silver carbonate; In tetrahydrofuran; hexane; water;

DOI:10.1080/00397910500516134

Reference yield:

2-chloro-3-trifluoromethyl-pyridine (65753-47-1) → 5-iodo-2-methoxy-3-(trifluoromethyl)pyridine (887707-27-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 73 percent / KOH / 2-methyl-propan-2-ol / 10 h / Heating

2: potassium carbonate; iodine / H₂O / 13 h / 20 - 50 °C

3: 920 mg / silver(I) carbonate / hexane; tetrahydrofuran / 25 h / 40 °C

With potassium hydroxide; iodine; potassium carbonate; silver carbonate; In tetrahydrofuran; hexane; water; tert-butyl alcohol;

DOI:10.1080/00397910500516134

upstream raw materials:

2-hydroxy-3-trifluoromethyl-5-(iodo)pyridine

methyl iodide

3-(trifluoromethyl)pyridin-2-ol

2-chloro-3-trifluoromethyl-pyridine

Downstream raw materials:

5-amino-2-methoxy-3-(trifluoromethyl)pyridine

2-methoxy-3-trifluoromethyl-5-pyridinemethanol

6-chloro-5-trifluoromethylpyridin-3-ylmethyl chloride

5-cyano-2-methoxy-3-trifluoromethylpyridine

Refernces