6-Methoxy-5-(trifluoromethyl)nicotinonitrile

Base Information

Chemical Name:6-Methoxy-5-(trifluoromethyl)nicotinonitrile
CAS No.:887707-29-1
Molecular Formula:C8H5F3N2O
Molecular Weight:202.13
Hs Code.:
DSSTox Substance ID:DTXSID20470605
Wikidata:Q82298757
Mol file:887707-29-1.mol

Synonyms:6-METHOXY-5-(TRIFLUOROMETHYL)NICOTINONITRILE;887707-29-1;2-METHOXY-3-(TRIFLUOROMETHYL)-5-CYANOPYRIDINE;6-methoxy-5-(trifluoromethyl)pyridine-3-carbonitrile;SCHEMBL2707348;DTXSID20470605;LMODEHOSNLUKSK-UHFFFAOYSA-N;MFCD09261085;AKOS027339366;AS-42365;FT-0695692;5-(Trifluoromethyl)-6-methoxypyridine-3-carbonitrile

Suppliers and Price of 6-Methoxy-5-(trifluoromethyl)nicotinonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
6-Methoxy-5-(trifluoromethyl)nicotinonitrile
50mg
$ 155.00

Crysdot
6-Methoxy-5-(trifluoromethyl)nicotinonitrile 97%
5g
$ 1657.00

Crysdot
6-Methoxy-5-(trifluoromethyl)nicotinonitrile 97%
1g
$ 472.00

Chemcia Scientific
6-Methoxy-5-trifluoromethyl-nicotinonitrile 95%
2.5 G
$ 900.00

American Custom Chemicals Corporation
2-METHOXY-3-(TRIFLUOROMETHYL)-5-CYANOPYRIDINE 95.00%
5MG
$ 502.29

Alichem
6-Methoxy-5-(trifluoromethyl)nicotinonitrile
1g
$ 3068.70

Alichem
6-Methoxy-5-(trifluoromethyl)nicotinonitrile
500mg
$ 1634.45

Total 9 raw suppliers

Chemical Property of 6-Methoxy-5-(trifluoromethyl)nicotinonitrile

Chemical Property:

PSA：45.91000
LogP:1.98068
XLogP3:1.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:1
Exact Mass:202.03539727
Heavy Atom Count:14
Complexity:245

Purity/Quality:

95% ^*data from raw suppliers

6-Methoxy-5-(trifluoromethyl)nicotinonitrile ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C(C=C(C=N1)C#N)C(F)(F)F

Technology Process of 6-Methoxy-5-(trifluoromethyl)nicotinonitrile

There total 4 articles about 6-Methoxy-5-(trifluoromethyl)nicotinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 887707-27-9
5-iodo-2-methoxy-3-(trifluoromethyl)pyridine

: 557-21-1
dicyanozinc

: 887707-29-1
5-cyano-2-methoxy-3-trifluoromethylpyridine

Guidance literature:: tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 80 ℃; for 8h;
DOI:10.1080/00397910500516134

Reference yield:

: 22245-83-6
3-(trifluoromethyl)pyridin-2-ol

: 887707-29-1
5-cyano-2-methoxy-3-trifluoromethylpyridine

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate; iodine / H₂O / 13 h / 20 - 50 °C

2: 920 mg / silver(I) carbonate / hexane; tetrahydrofuran / 25 h / 40 °C

3: 82 percent / tetrakis(triphenylphosphine)palladium⁽⁰⁾ / dimethylformamide / 8 h / 80 °C

With iodine; potassium carbonate; silver carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; hexane; water; N,N-dimethyl-formamide;
DOI:10.1080/00397910500516134

Reference yield:

: 887707-23-5
2-hydroxy-3-trifluoromethyl-5-(iodo)pyridine

: 887707-29-1
5-cyano-2-methoxy-3-trifluoromethylpyridine

Guidance literature:: Multi-step reaction with 2 steps

1: 920 mg / silver(I) carbonate / hexane; tetrahydrofuran / 25 h / 40 °C

2: 82 percent / tetrakis(triphenylphosphine)palladium⁽⁰⁾ / dimethylformamide / 8 h / 80 °C

With silver carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;
DOI:10.1080/00397910500516134