1-HYDROXYMETHYL-3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBOXYLIC ACID TERT-BUTYL ESTER

Base Information

• Chemical Name: 1-HYDROXYMETHYL-3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBOXYLIC ACID TERT-BUTYL ESTER
• CAS No.: 954239-58-8
• Molecular Formula: C₁₅H₂₁NO₃
• Molecular Weight: 263.337
• Mol file: 954239-58-8.mol

Synonyms:1-HYDROXYMETHYL-3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBOXYLIC ACID TERT-BUTYL ESTER;2(1H)-Isoquinolinecarboxylic acid, 3,4-dihydro-1-(hydroxymethyl)-, 1,1-dimethylethyl ester;tert-butyl 1-(hydroxyMethyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate;3,4-Dihydro-1-(hydroxymethyl)-2(1H)-isoquinolinecarboxylic acid 1,1-dimethylethyl ester

Chemical Property of 1-HYDROXYMETHYL-3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBOXYLIC ACID TERT-BUTYL ESTER

Chemical Property:

• Vapor Pressure: 7.07E-07mmHg at 25°C
• Boiling Point: 392.9°C at 760 mmHg
• Flash Point: 191.4°C
• PSA: 49.77000
• Density: 1.129g/cm³
• LogP: 2.45110

Purity/Quality:

97% ^*data from raw suppliers

1-Hydroxymethyl-3,4-dihydro-1H-isoquinoline-2-carboxylicacidtert-butylester 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-HYDROXYMETHYL-3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBOXYLIC ACID TERT-BUTYL ESTER

There total 4 articles about 1-HYDROXYMETHYL-3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBOXYLIC ACID TERT-BUTYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

(1R)-2-[(tert-butyl) oxycarbonyl]-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid (151004-96-5) → (1R)-1-hydroxymethyl-2-[(tert-butyl) oxycarbonyl]-1,2,3,4-tetrahydroisoquinoline (954239-58-8)

Guidance literature:

With borane; In tetrahydrofuran; at 0 ℃; for 3h; Inert atmosphere; Green chemistry;

Reference yield:

(R)-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid potassium salt → (1R)-1-hydroxymethyl-2-[(tert-butyl) oxycarbonyl]-1,2,3,4-tetrahydroisoquinoline (954239-58-8)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogenchloride / water / pH 2-3 / Green chemistry

2: ozone; sodium carbonate / water; tetrahydrofuran / 0 °C / Green chemistry

3: borane / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere; Green chemistry

With hydrogenchloride; borane; sodium carbonate; ozone; In tetrahydrofuran; water;

Reference yield:

(R)-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid (151004-93-2) → (1R)-1-hydroxymethyl-2-[(tert-butyl) oxycarbonyl]-1,2,3,4-tetrahydroisoquinoline (954239-58-8)

Guidance literature:

Multi-step reaction with 2 steps

1: ozone; sodium carbonate / water; tetrahydrofuran / 0 °C / Green chemistry

2: borane / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere; Green chemistry

With borane; sodium carbonate; ozone; In tetrahydrofuran; water;

upstream raw materials:

(R)-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid

(1R)-2-[(tert-butyl) oxycarbonyl]-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid

1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid

Downstream raw materials:

(-)-Praziquantel

N-[(R)-1-(1,2,3,4-tetrahydroisoquinolin-1-ylmethyl)]cyclohexanecarboxylic acid amide

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 954239-58-8 1-HYDROXYMETHYL-3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBOXYLIC ACID TERT-BUTYL ESTER

Send

Send

Metric Ton KG G Pound L ML

Send

Send