1,2(1H)-Isoquinolinedicarboxylic acid, 3,4-dihydro-, 2-(1,1-diMethylethyl) ester, (1R)-

Base Information

• Chemical Name: 1,2(1H)-Isoquinolinedicarboxylic acid, 3,4-dihydro-, 2-(1,1-diMethylethyl) ester, (1R)-
• CAS No.: 151004-96-5
• Molecular Formula: C₁₅H₁₉NO₄
• Molecular Weight: 277.32
• Hs Code.: 2933499090
• Mol file: 151004-96-5.mol

Synonyms:1,2(1H)-Isoquinolinedicarboxylic acid, 3,4-dihydro-, 2-(1,1-diMethylethyl) ester, (1R)-;(R)-2-Boc-3,4-dihydro-1H-isoquinoline-1-carboxylic acid;(R) -2- (tert-butoxycarbonyl) -1,2,3,4-tetrahydro-isoquinoline-carboxylic acid

Chemical Property of 1,2(1H)-Isoquinolinedicarboxylic acid, 3,4-dihydro-, 2-(1,1-diMethylethyl) ester, (1R)-

Chemical Property:

• PSA: 66.84000
• LogP: 2.54340
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

(R)-2-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydro-isoquinoline-1-carboxylic acid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,2(1H)-Isoquinolinedicarboxylic acid, 3,4-dihydro-, 2-(1,1-diMethylethyl) ester, (1R)-

There total 3 articles about 1,2(1H)-Isoquinolinedicarboxylic acid, 3,4-dihydro-, 2-(1,1-diMethylethyl) ester, (1R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

di-tert-butyl dicarbonate (24424-99-5) + (R)-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid (151004-93-2) → (1R)-2-[(tert-butyl) oxycarbonyl]-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid (151004-96-5)

Guidance literature:

With sodium carbonate; ozone; In tetrahydrofuran; water; at 0 ℃; Green chemistry;

Reference yield:

(R)-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid potassium salt → (1R)-2-[(tert-butyl) oxycarbonyl]-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid (151004-96-5)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / water / pH 2-3 / Green chemistry

2: ozone; sodium carbonate / water; tetrahydrofuran / 0 °C / Green chemistry

With hydrogenchloride; sodium carbonate; ozone; In tetrahydrofuran; water;

Reference yield:

1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid (41034-52-0) → (1R)-2-[(tert-butyl) oxycarbonyl]-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid (151004-96-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: oxygen; D-amino acid oxidase; N-tert-butylaminoborane / aq. phosphate buffer / 35 h / 35 °C / pH 8.2 / Green chemistry; Enzymatic reaction

1.2: 50 - 60 °C / Green chemistry

2.1: hydrogenchloride / water / pH 2-3 / Green chemistry

3.1: ozone; sodium carbonate / water; tetrahydrofuran / 0 °C / Green chemistry

With hydrogenchloride; D-amino acid oxidase; N-tert-butylaminoborane; oxygen; sodium carbonate; ozone; In tetrahydrofuran; aq. phosphate buffer; water;

upstream raw materials:

di-tert-butyl dicarbonate

(R)-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid

1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid

Downstream raw materials:

(1R)-1-hydroxymethyl-2-[(tert-butyl) oxycarbonyl]-1,2,3,4-tetrahydroisoquinoline

(-)-Praziquantel

N-[(R)-1-(1,2,3,4-tetrahydroisoquinolin-1-ylmethyl)]cyclohexanecarboxylic acid amide