2-cyclopropyl-5-phenyl-N-(pyridin-2-ylmethyl)quinazolin-4-amine

Base Information

Chemical Name:2-cyclopropyl-5-phenyl-N-(pyridin-2-ylmethyl)quinazolin-4-amine
CAS No.:1272353-78-2
Molecular Formula:C₂₃H₂₀N₄
Molecular Weight:352.439
Hs Code.:
Mol file:1272353-78-2.mol

Synonyms:2-cyclopropyl-5-phenyl-N-(pyridin-2-ylmethyl)quinazolin-4-amine

Suppliers and Price of 2-cyclopropyl-5-phenyl-N-(pyridin-2-ylmethyl)quinazolin-4-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 2-cyclopropyl-5-phenyl-N-(pyridin-2-ylmethyl)quinazolin-4-amine

Chemical Property:

Purity/Quality:: 98%min ^*data from raw suppliers

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Technology Process of 2-cyclopropyl-5-phenyl-N-(pyridin-2-ylmethyl)quinazolin-4-amine

There total 6 articles about 2-cyclopropyl-5-phenyl-N-(pyridin-2-ylmethyl)quinazolin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 7.0%

: 1272353-93-1
2-chloro-5-phenyl-N-(pyridin-2-ylmethyl)quinazolin-4-amine

: 23719-80-4
cyclopropylmagnesium bromide

: 1272353-78-2
2-cyclopropyl-5-phenyl-N-(pyridin-2-ylmethyl)quinazolin-4-amine

Guidance literature:: With zinc dibromide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; at -78 - 20 ℃; for 19h;

Reference yield:

: 20780-72-7
4-bromoisatin

: 1272353-78-2
2-cyclopropyl-5-phenyl-N-(pyridin-2-ylmethyl)quinazolin-4-amine

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydroxide; dihydrogen peroxide / 1.25 h / 80 °C

1.2: pH 4 - 5

2.1: acetic acid / water / 35 °C

3.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 40 h / Reflux

4.1: trichlorophosphate; N,N-dimethyl-aniline / 2 h / 105 °C

5.1: triethylamine / tetrahydrofuran / 14 h / 20 °C

6.1: zinc dibromide / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / tetrahydrofuran / 19 h / -78 - 20 °C

With dihydrogen peroxide; sodium hydrogencarbonate; acetic acid; N,N-dimethyl-aniline; triethylamine; sodium hydroxide; zinc dibromide; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,2-dimethoxyethane; water;

Reference yield:

: 959237-01-5
5-bromoquinazoline-2,4(1H,3H)-dione

: 1272353-78-2
2-cyclopropyl-5-phenyl-N-(pyridin-2-ylmethyl)quinazolin-4-amine

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 40 h / Reflux

2: trichlorophosphate; N,N-dimethyl-aniline / 2 h / 105 °C

3: triethylamine / tetrahydrofuran / 14 h / 20 °C

4: zinc dibromide / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / tetrahydrofuran / 19 h / -78 - 20 °C

With sodium hydrogencarbonate; N,N-dimethyl-aniline; triethylamine; zinc dibromide; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,2-dimethoxyethane; water;