4-[2-[1-(3-Azetidinyl)-1H-pyrazol-5-yl]-4-(trifluoroMethyl)phenoxy]-5-chloro-2-fluoro-N-1,3,4-thiadiazol-2-yl benzenesulfonaMide

Base Information

Chemical Name:4-[2-[1-(3-Azetidinyl)-1H-pyrazol-5-yl]-4-(trifluoroMethyl)phenoxy]-5-chloro-2-fluoro-N-1,3,4-thiadiazol-2-yl benzenesulfonaMide
CAS No.:1354818-96-4
Molecular Formula:C21H15ClF4N6O3S2
Molecular Weight:574.967
Hs Code.:
Mol file:1354818-96-4.mol

Synonyms:4-[2-[1-(3-Azetidinyl)-1H-pyrazol-5-yl]-4-(trifluoroMethyl)phenoxy]-5-chloro-2-fluoro-N-1,3,4-thiadiazol-2-yl benzenesulfonaMide;4-(2-(1-(Azetidin-3-yl)-1H-pyrazol-5-yl)-4-(trifluoromethyl)phenoxy)-5-chloro-2-fluoro-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide

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Chemical Property of 4-[2-[1-(3-Azetidinyl)-1H-pyrazol-5-yl]-4-(trifluoroMethyl)phenoxy]-5-chloro-2-fluoro-N-1,3,4-thiadiazol-2-yl benzenesulfonaMide

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Purity/Quality:: 97% ^*data from raw suppliers

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Technology Process of 4-[2-[1-(3-Azetidinyl)-1H-pyrazol-5-yl]-4-(trifluoroMethyl)phenoxy]-5-chloro-2-fluoro-N-1,3,4-thiadiazol-2-yl benzenesulfonaMide

There total 6 articles about 4-[2-[1-(3-Azetidinyl)-1H-pyrazol-5-yl]-4-(trifluoroMethyl)phenoxy]-5-chloro-2-fluoro-N-1,3,4-thiadiazol-2-yl benzenesulfonaMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1354819-31-0
tert-butyl 3-{5-[5-trifluoromethyl-2-(2-chloro-4-{[(2,4-dimethoxybenzyl)(1,3,4-thiadiazol-5-yl)amino]sulfonyl}-5-fluorophenoxy)phenyl]-1H-pyrazol-1-yl}azetidine-1-carboxylate

: 1354818-96-4
4-[2-(1-azetidin-3-yl-1H-pyrazol-5-yl)-5-chloro-2-fluoro-4-(trifluoromethyl)phenoxy]-N-1,3,4-thiadiazol-5-yl benzenesulfonamide

Guidance literature:: tert-butyl 3-{5-[5-trifluoromethyl-2-(2-chloro-4-{[(2,4-dimethoxybenzyl)(1,3,4-thiadiazol-5-yl)amino]sulfonyl}-5-fluorophenoxy)phenyl]-1H-pyrazol-1-yl}azetidine-1-carboxylate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2.5h;

With ammonia; In water;

Reference yield:

: 67589-15-5
1-(2-hydroxy-5-(trifluoromethyl)phenyl)ethan-1-one

: 1354818-96-4
4-[2-(1-azetidin-3-yl-1H-pyrazol-5-yl)-5-chloro-2-fluoro-4-(trifluoromethyl)phenoxy]-N-1,3,4-thiadiazol-5-yl benzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: 0.5 h / 110 °C

2: acetic acid / ethanol / 0 - 20 °C

3: potassium carbonate / dimethyl sulfoxide / 3 h / 20 °C

4: trifluoroacetic acid / dichloromethane / 2.5 h / 20 °C

With potassium carbonate; acetic acid; trifluoroacetic acid; In ethanol; dichloromethane; dimethyl sulfoxide;

Reference yield:

: 503464-99-1
1-(2-methoxy-5-(trifluoromethyl)phenyl)ethan-1-one

: 1354818-96-4
4-[2-(1-azetidin-3-yl-1H-pyrazol-5-yl)-5-chloro-2-fluoro-4-(trifluoromethyl)phenoxy]-N-1,3,4-thiadiazol-5-yl benzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: boron tribromide; tetra-(n-butyl)ammonium iodide / dichloromethane / 0 - 20 °C

1.2: Cooling with ice

2.1: 0.5 h / 110 °C

3.1: acetic acid / ethanol / 0 - 20 °C

4.1: potassium carbonate / dimethyl sulfoxide / 3 h / 20 °C

5.1: trifluoroacetic acid / dichloromethane / 2.5 h / 20 °C

With boron tribromide; tetra-(n-butyl)ammonium iodide; potassium carbonate; acetic acid; trifluoroacetic acid; In ethanol; dichloromethane; dimethyl sulfoxide;