2-Propanol, 1-[(2-broMo-5-fluoro-4-nitrophenyl)aMino]-3-(phenylMethoxy)-, (2R)-

Base Information

Chemical Name:2-Propanol, 1-[(2-broMo-5-fluoro-4-nitrophenyl)aMino]-3-(phenylMethoxy)-, (2R)-
CAS No.:1342896-73-4
Molecular Formula:C16H16BrFN2O4
Molecular Weight:399.216
Hs Code.:
Mol file:1342896-73-4.mol

Synonyms:2-Propanol, 1-[(2-broMo-5-fluoro-4-nitrophenyl)aMino]-3-(phenylMethoxy)-, (2R)-;2-Propanol, 1-[(2-broMo-5-fluoro-4-nitrophenyl)aMino]-3-(phenylMethoxy)-, (2R)-4

Suppliers and Price of 2-Propanol, 1-[(2-broMo-5-fluoro-4-nitrophenyl)aMino]-3-(phenylMethoxy)-, (2R)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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Total 2 raw suppliers

Chemical Property of 2-Propanol, 1-[(2-broMo-5-fluoro-4-nitrophenyl)aMino]-3-(phenylMethoxy)-, (2R)-

Chemical Property:

Purity/Quality:: 98%+ ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-Propanol, 1-[(2-broMo-5-fluoro-4-nitrophenyl)aMino]-3-(phenylMethoxy)-, (2R)-

There total 4 articles about 2-Propanol, 1-[(2-broMo-5-fluoro-4-nitrophenyl)aMino]-3-(phenylMethoxy)-, (2R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: (2R)-1-(benzyloxy)-3-(3-fluoro-4-nitroanilino)propan-2-ol

: 1342896-73-4
(R)-1-(benzyloxy)-3-(2-bromo-5-fluoro-4-nitrophenylamino)propan-2-ol

Guidance literature:: With N-Bromosuccinimide; In ethyl acetate; at 20 ℃; for 1h;

Reference yield: 70.0%

: 952664-69-6
2-bromo-5-fluoro-4-nitroaniline

: 14618-80-5
(R)-benzyl glycidol

: 1342896-73-4
(R)-1-(benzyloxy)-3-(2-bromo-5-fluoro-4-nitrophenylamino)propan-2-ol

Guidance literature:: 2-bromo-5-fluoro-4-nitroaniline; With zinc(II) perchlorate; In toluene; at 20 ℃; for 2h; Molecular sieve; Inert atmosphere;

(R)-benzyl glycidol; In toluene; at 85 ℃; for 15h; Molecular sieve; Inert atmosphere;

Reference yield:

: 2930-05-4,14618-80-5,89616-40-0,16495-13-9
(S)-benzyl glycidyl ether

: 1342896-73-4
(R)-1-(benzyloxy)-3-(2-bromo-5-fluoro-4-nitrophenylamino)propan-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1: iron(III) chloride / ethyl acetate / 2 h / 20 - 28 °C

2: N-Bromosuccinimide / ethyl acetate / 1 h / 20 °C

With iron(III) chloride; N-Bromosuccinimide; In ethyl acetate;