2-Propanol, 1-[[4-aMino-2-[3,3-diMethyl-4-(phenylMethoxy)-1-butyn-1-yl]-5-fluorophenyl]aMino]-3-(phenylMethoxy)-, (2R)-

Base Information

Chemical Name:2-Propanol, 1-[[4-aMino-2-[3,3-diMethyl-4-(phenylMethoxy)-1-butyn-1-yl]-5-fluorophenyl]aMino]-3-(phenylMethoxy)-, (2R)-
CAS No.:1294504-66-7
Molecular Formula:C29H33FN2O3
Molecular Weight:476.591
Hs Code.:

Synonyms:2-Propanol, 1-[[4-aMino-2-[3,3-diMethyl-4-(phenylMethoxy)-1-butyn-1-yl]-5-fluorophenyl]aMino]-3-(phenylMethoxy)-, (2R)-;2-Propanol, 1-[[4-aMino-2-[3,3-diMethyl-4-(phenylMethoxy)-1-butyn-1-yl]-5-fluorophenyl]aMino]-3-(phenylMethoxy)-, (2R)-7

Suppliers and Price of 2-Propanol, 1-[[4-aMino-2-[3,3-diMethyl-4-(phenylMethoxy)-1-butyn-1-yl]-5-fluorophenyl]aMino]-3-(phenylMethoxy)-, (2R)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of 2-Propanol, 1-[[4-aMino-2-[3,3-diMethyl-4-(phenylMethoxy)-1-butyn-1-yl]-5-fluorophenyl]aMino]-3-(phenylMethoxy)-, (2R)-

Chemical Property:

PSA：76.74000
LogP:5.64620

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-Propanol, 1-[[4-aMino-2-[3,3-diMethyl-4-(phenylMethoxy)-1-butyn-1-yl]-5-fluorophenyl]aMino]-3-(phenylMethoxy)-, (2R)-

There total 12 articles about 2-Propanol, 1-[[4-aMino-2-[3,3-diMethyl-4-(phenylMethoxy)-1-butyn-1-yl]-5-fluorophenyl]aMino]-3-(phenylMethoxy)-, (2R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1092536-54-3
[{(2,2-dimethylbut-3-yn-1-yl)oxy}methyl]benzene

: 1294504-64-5
(R)-1-((4-amino-2-bromo-5-fluorophenyl)amino)-3-(benzyloxy)propan-2-ol p-toluenesulfonic acid salt

: 1294504-66-7
(R)-1-((4-amino-2-(4-(benzyloxy)-3,3-dimethylbut-1-yn-1-yl)-5-fluorophenyl)amino)-3-(benzyloxy)propan-2-ol

Guidance literature:: With palladium diacetate; potassium carbonate; 1,4-di(diphenylphosphino)-butane; In acetonitrile; at 80 ℃; for 16h; Inert atmosphere;

Reference yield: 64.3%

: 1092536-54-3
[{(2,2-dimethylbut-3-yn-1-yl)oxy}methyl]benzene

: 1294504-63-4
(R)-1-(4-amino-2-bromo-5-fluorophenylamino)-3-(benzyloxy)propan-2-ol

: 1294504-66-7
(R)-1-((4-amino-2-(4-(benzyloxy)-3,3-dimethylbut-1-yn-1-yl)-5-fluorophenyl)amino)-3-(benzyloxy)propan-2-ol

Guidance literature:: With copper(l) iodide; palladium diacetate; potassium carbonate; 1,4-di(diphenylphosphino)-butane; In acetonitrile; at 20 - 80 ℃; Inert atmosphere;

Reference yield:

: 5272-33-3
2-methyl-4-(trimethylsilyl)but-3-yn-2-ol

: 1294504-66-7
(R)-1-((4-amino-2-(4-(benzyloxy)-3,3-dimethylbut-1-yn-1-yl)-5-fluorophenyl)amino)-3-(benzyloxy)propan-2-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride / water / 16 h

2.1: magnesium / tetrahydrofuran / 3.5 h / Inert atmosphere

2.2: 16 h / 25 °C

3.1: potassium hydroxide / methanol / 25 °C

4.1: palladium diacetate; potassium carbonate; 1,4-di(diphenylphosphino)-butane / acetonitrile / 1 h / Inert atmosphere; Large scale

4.2: 16 h / 80 °C / Large scale

With hydrogenchloride; palladium diacetate; potassium carbonate; magnesium; 1,4-di(diphenylphosphino)-butane; potassium hydroxide; In tetrahydrofuran; methanol; water; acetonitrile;