5-Hydroxy-1H-indole-3-acetic acid methyl ester

Base Information

• Chemical Name: 5-Hydroxy-1H-indole-3-acetic acid methyl ester
• CAS No.: 15478-18-9
• Molecular Formula: C11H11NO3
• Molecular Weight: 205.213
• Hs Code.: 2933990090
• Mol file: 15478-18-9.mol

Synonyms:5-Hydroxy-1H-indole-3-acetic acid methyl ester;methyl 2-(5-hydroxy-1H-indol-3-yl)acetate

Chemical Property of 5-Hydroxy-1H-indole-3-acetic acid methyl ester

Chemical Property:

• PSA: 62.32000
• LogP: 1.58900

Purity/Quality:

97% ^*data from raw suppliers

Methyl5-Hydroxy-3-indoleacetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Methyl 5-Hydroxy-3-indoleacetate is an intermediate in the synthesis of 5-Hydroxyindole-3-acetic Acid-D5 (H953609). 5-Hydroxyindole-3-acetic Acid-D5 is a labelled analogue of 5-Hydroxyindole-3-acetic Acid (H953605). 5-Hydroxyindole-3-acetic Acid is an impurity of Chlorpheniramine (C424300), a histamine H1 receptor antagonist that is used to treat allergy symptoms..

Technology Process of 5-Hydroxy-1H-indole-3-acetic acid methyl ester

There total 9 articles about 5-Hydroxy-1H-indole-3-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

methanol (67-56-1) + 5-Hydroxyindole-3-acetic acid (54-16-0,1321-73-9) → (5-hydroxy-1H-indol-3-yl)acetic acid methyl ester (15478-18-9)

Guidance literature:

With acetyl chloride; at 20 ℃; for 2h;

Reference yield: 72.0%

(5-methoxy-1H-indol-3-yl)acetic acid methyl ester (23304-48-5) → (5-hydroxy-1H-indol-3-yl)acetic acid methyl ester (15478-18-9)

Guidance literature:

(5-methoxy-1H-indol-3-yl)acetic acid methyl ester; With aluminum (III) chloride; In dichloromethane; at 0 ℃; for 0.5h;

With ethanethiol; In dichloromethane; at 0 - 20 ℃; for 4h;

DOI:10.1016/j.bmc.2015.04.046

Reference yield:

(5-hydroxy-1H-indol-3-yl)-oxo-acetic acid methyl ester (425640-22-8) → (5-hydroxy-1H-indol-3-yl)acetic acid methyl ester (15478-18-9)

Guidance literature:

With sodium hypophosphite monohydrate; palladium 10% on activated carbon; In 1,4-dioxane; water; for 1.5h; Reflux;

upstream raw materials:

methanol

5-Hydroxyindole-3-acetic acid

indol-5-ol

(5-hydroxy-1H-indol-3-yl)-oxo-acetic acid methyl ester

Downstream raw materials:

[5-[3-(benzooxazol-2-ylmethylamino)propoxy]-1-(4-fluorobenzyl)-1H-indol-3-yl]acetic acid methyl ester

[5-[3-(benzooxazol-2-ylmethylamino)propoxy]-1-(4-fluorobenzyl)-1H-indol-3-yl]acetic acid

[5-[3-(benzooxazol-2-ylmethylamino)propoxy]-1-(4-chlorobenzoyl)-1H-indol-3-yl]acetic acid methyl ester

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