2-Amino-1-(3,4-difluorophenyl)ethanol

Base Information

• Chemical Name: 2-Amino-1-(3,4-difluorophenyl)ethanol
• CAS No.: 10145-04-7
• Molecular Formula: C8H9F2NO
• Molecular Weight: 173.162
• Hs Code.: 2922199090
• ChEMBL ID: CHEMBL4513749
• DSSTox Substance ID: DTXSID90588049
• Nikkaji Number: J532.129H
• Mol file: 10145-04-7.mol

Synonyms:2-amino-1-(3,4-difluorophenyl)ethanol;10145-04-7;2-amino-1-(3,4-difluorophenyl)ethan-1-ol;Benzenemethanol, alpha-(aminomethyl)-3,4-difluoro-;SCHEMBL3403672;CHEMBL4513749;DTXSID90588049;CXJWXUGRWAXKAF-UHFFFAOYSA-N;MFCD09042070;AKOS000124033;AKOS016051391;MCULE-6569064980;2-amino-1-(3,4-difluorophenyl)-ethanol;2-amino-1-(3,4-difluoro-phenyl)-ethanol;DB-292561;CS-0416094;EN300-36696;C77696;Benzenemethanol, |A-(aminomethyl)-3,4-difluoro-;Z330910382

Chemical Property of 2-Amino-1-(3,4-difluorophenyl)ethanol

Chemical Property:

• PSA: 46.25000
• LogP: 1.65720
• XLogP3: -0.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 173.06522023
• Heavy Atom Count: 12
• Complexity: 145

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Amino-1-(3,4-difluorophenyl)ethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(C=C1C(CN)O)F)F

Technology Process of 2-Amino-1-(3,4-difluorophenyl)ethanol

There total 7 articles about 2-Amino-1-(3,4-difluorophenyl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-azido-1-(3,4-difluorophenyl)ethanol (1021939-57-0) → 2-amino-1-(3,4-difluoro-phenyl)-ethanol (10145-04-7)

Guidance literature:

With hydrogen; palladium on activated carbon; In ethanol;

Reference yield:

trimethylsilyl cyanide (7677-24-9) + 3,4 difluorobenzaldehyde (34036-07-2) → 2-amino-1-(3,4-difluoro-phenyl)-ethanol (10145-04-7)

Guidance literature:

trimethylsilyl cyanide; 3,4 difluorobenzaldehyde; With zinc(II) iodide; In tetrahydrofuran; at 0 ℃; for 3.5h; Inert atmosphere;

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 21h; Inert atmosphere;

With water; sodium hydroxide; In tetrahydrofuran; at 0 ℃; for 1h; Inert atmosphere;

Reference yield:

2-(3,4-Difluorophenyl)-2-hydroxyacetonitrile (181641-00-9) + diethyl ether (60-29-7,927820-24-4) → 2-amino-1-(3,4-difluoro-phenyl)-ethanol (10145-04-7)

Guidance literature:

With sodium hydroxide; LiAlH₄; In water;

upstream raw materials:

2-chloro-1-(3,4-difluorophenyl)ethanol

ortho-difluorobenzene

2-chloro-1-(3,4-difluorophenyl)ethan-1-one

2-(3,4-Difluorophenyl)-2-hydroxyacetonitrile

Downstream raw materials:

[1-(3,4-difluorophenyl)-2-hydroxy-ethyl]-carbamic acid-tert-butyl ester

[2-(3,4-difluorophenyl)-2-hydroxy-ethyl]-carbamic acid-tert-butyl ester

N-[2-(3,4-difluorophenyl)-2-hydroxyethyl]-3-[1-[(dimethylamino)sulfonyl]-4-(2,2-dimethylbutyl)-1H-imidazol-2-yl]propanamide

4-(3,4-difluorophenyl)-2-oxazolidinone