2-Amino-1-cyclopropylethanol

Base Information

• Chemical Name: 2-Amino-1-cyclopropylethanol
• CAS No.: 54120-02-4
• Molecular Formula: C5H11NO
• Molecular Weight: 101.148
• European Community (EC) Number: 826-932-5
• Nikkaji Number: J2.639.655G
• Mol file: 54120-02-4.mol

Synonyms:2-AMINO-1-CYCLOPROPYLETHANOL;2-amino-1-cyclopropylethan-1-ol;54120-02-4;(1R)-2-amino-1-cyclopropyl-ethanol;MFCD11043287;a-(Aminomethyl)-cyclopropanemethanol HCl;2-Amino-1-cyclopropyl-ethanol;SCHEMBL937861;JCAJMHONCHYTCA-UHFFFAOYSA-N;AKOS010564532;SB74864;SB84088;BS-12737;SY186959;CS-0128611;EN300-67533;V10284;A904374;F8881-1739;Z802856322

Chemical Property of 2-Amino-1-cyclopropylethanol

Chemical Property:

• PSA: 46.25000
• LogP: 0.41630
• XLogP3: -0.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 101.084063974
• Heavy Atom Count: 7
• Complexity: 61.1

Purity/Quality:

98% ^*data from raw suppliers

2-Amino-1-cyclopropylethan-1-ol 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC1C(CN)O

Technology Process of 2-Amino-1-cyclopropylethanol

There total 4 articles about 2-Amino-1-cyclopropylethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-(cyclopropyl)-2-nitroethanol (54120-03-5) → 2-amino-(1RS)-1-cyclopropylethanol (54120-02-4)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; for 24h; under 1654.92 Torr;

Reference yield: 30.0%

trimethylsilyl cyanide (7677-24-9) + Cyclopropanecarboxaldehyde (1489-69-6) → 2-amino-(1RS)-1-cyclopropylethanol (54120-02-4)

Guidance literature:

trimethylsilyl cyanide; Cyclopropanecarboxaldehyde; With zinc(II) iodide; In dichloromethane; at 0 - 20 ℃; for 3h;

With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 3h; Cooling with ice;

Reference yield:

2-cyclopropyl-2-hydroxyacetonitrile (5648-87-3) → 2-amino-(1RS)-1-cyclopropylethanol (54120-02-4)

Guidance literature:

2-cyclopropyl-2-hydroxyacetonitrile; With lithium aluminium tetrahydride; In diethyl ether; at 0 - 20 ℃; for 1h;

With sodium hydroxide; water; In diethyl ether;

upstream raw materials:

1-(cyclopropyl)-2-nitroethanol

2-cyclopropyl-2-hydroxyacetonitrile

2-cyclopropyl-2-((trimethylsilyl)oxy)acetonitrile

trimethylsilyl cyanide

Downstream raw materials:

2-cyclopropylacetaldehyde

2-t-butoxycarbonylamino-1-cyclopropylethanol

2-cyclopropyl-N-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)-4-methyl-2,3,4,5-tetrahydropyrido[3,2-f][1,4]oxazepin-8-amine

2-cyclopropylmorpholine

Refernces

• 1、 Aubineau, Thomas,Cossy, Janine. "A One-Pot Reaction toward the Diastereoselective Synthesis of Substituted Morpholines". supporting information. p. 7419 - 7423. Retrieved 2018/12/11.
• 2、 -. "Piperazine derivatives and their use as therapeutic agents". Paragraph 0109. . Retrieved 2016/03/19.