FMOC-D-MET-OPFP

Base Information

• Chemical Name: FMOC-D-MET-OPFP
• CAS No.: 210473-10-2
• Molecular Formula: C26H20F5NO4S
• Molecular Weight: 537.5
• Mol file: 210473-10-2.mol

Synonyms:FMOC-D-MET-OPFP;FMOC-D-METHIONINE PENTAFLUOROPHENYL ESTER;N-ALPHA-FMOC-D-METHIONINE PENTAFLUOROPHENYL ESTER;N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-methionine pentafluorophenyl ester

Chemical Property of FMOC-D-MET-OPFP

Chemical Property:

• PSA: 93.42000
• LogP: 6.15230
• Storage Temp.: Store at 0°C

Purity/Quality:

98% ^*data from raw suppliers

Fmoc-D-Met-OPfp 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of FMOC-D-MET-OPFP

There total 7 articles about FMOC-D-MET-OPFP which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine (71989-28-1) + pentafluorophenyl 4-nitrobenzenesulfonate (244633-31-6) → N-α-Fmoc-L-methionine pentafluorophenyl ester (86060-94-8,210473-10-2)

Guidance literature:

With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/S0040-4039(99)01178-8

Reference yield: 93.0%

2,3,4,5,6-pentafluorophenol (771-61-9) + N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine (71989-28-1) → N-α-Fmoc-L-methionine pentafluorophenyl ester (86060-94-8,210473-10-2)

Guidance literature:

With dicyclohexyl-carbodiimide; In ethyl acetate; 0 deg C, 1 h; r.t., 1 h;

DOI:10.1055/s-1983-30327

Reference yield: 90.0%

2,3,4,5,6-pentafluorophenol (771-61-9) + Fmoc-methioninechloride (103321-54-6) → N-α-Fmoc-L-methionine pentafluorophenyl ester (86060-94-8,210473-10-2)

Guidance literature:

With pyridine; In tetrahydrofuran; at 4 ℃;

DOI:10.1016/0040-4039(91)80788-8

upstream raw materials:

2,3,4,5,6-pentafluorophenol

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine

Fmoc-methioninechloride

pentafluorophenyl 4-nitrobenzenesulfonate

Downstream raw materials:

Fmoc-Met-ol

C₆₉H₁₀₄N₁₈O₁₅S

C₈₂H₁₁₅N₂₁O₁₆S

C₇₁H₁₀₅N₁₉O₁₅S