benzoic acid (2R,3S,4S,5S)-5-azido-2-(2,4-dioxo-3,4-dihydro-2H-pyriMidin-1-yl)-4-fluoro-5-iodoMethyl-tetrahydro-furan-3-yl esterine-2,4-dione

Base Information

Chemical Name:benzoic acid (2R,3S,4S,5S)-5-azido-2-(2,4-dioxo-3,4-dihydro-2H-pyriMidin-1-yl)-4-fluoro-5-iodoMethyl-tetrahydro-furan-3-yl esterine-2,4-dione
CAS No.:1444430-74-3
Molecular Formula:C16H13FIN5O5
Molecular Weight:501.213
Hs Code.:
Mol file:1444430-74-3.mol

Synonyms:benzoic acid (2R,3S,4S,5S)-5-azido-2-(2,4-dioxo-3,4-dihydro-2H-pyriMidin-1-yl)-4-fluoro-5-iodoMethyl-tetrahydro-furan-3-yl esterine-2,4-dione

Suppliers and Price of benzoic acid (2R,3S,4S,5S)-5-azido-2-(2,4-dioxo-3,4-dihydro-2H-pyriMidin-1-yl)-4-fluoro-5-iodoMethyl-tetrahydro-furan-3-yl esterine-2,4-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 3 raw suppliers

Chemical Property of benzoic acid (2R,3S,4S,5S)-5-azido-2-(2,4-dioxo-3,4-dihydro-2H-pyriMidin-1-yl)-4-fluoro-5-iodoMethyl-tetrahydro-furan-3-yl esterine-2,4-dione

Chemical Property:

PSA：140.14000
LogP:1.52346

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

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Technology Process of benzoic acid (2R,3S,4S,5S)-5-azido-2-(2,4-dioxo-3,4-dihydro-2H-pyriMidin-1-yl)-4-fluoro-5-iodoMethyl-tetrahydro-furan-3-yl esterine-2,4-dione

There total 4 articles about benzoic acid (2R,3S,4S,5S)-5-azido-2-(2,4-dioxo-3,4-dihydro-2H-pyriMidin-1-yl)-4-fluoro-5-iodoMethyl-tetrahydro-furan-3-yl esterine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1145869-43-7
1-((2R,3S,4S,5S)-5-azido-4-fluoro-3-hydroxy-5-iodomethyl-tetrahydro-furan-2-yl)-1H-pyrimidine-2,4-dione

: 98-88-4
benzoyl chloride

: 1444430-74-3
benzoic acid (2R,3S,4S,5S)-5-azido-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-fluoro-5-iodomethyl-tetrahydro-furan-3-yl esterine-2,4-dione

Guidance literature:: With dmap; In tetrahydrofuran; at 0 ℃; for 0.0833333h; Inert atmosphere;

Reference yield:

: 57944-13-5
3'-fluoro-3'-desoxyuridine

: 1444430-74-3
benzoic acid (2R,3S,4S,5S)-5-azido-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-fluoro-5-iodomethyl-tetrahydro-furan-3-yl esterine-2,4-dione

Guidance literature:: Multi-step reaction with 4 steps

1: triphenylphosphine; pyridine; iodine / acetonitrile / 12 h / 20 °C / Inert atmosphere

2: sodium methylate / methanol / 2 h / Reflux

3: N-benzyl-N,N,N-triethylammonium chloride; sodium azide; 4-methyl-morpholine; iodine / acetonitrile; tetrahydrofuran / 0 - 9 °C / Cooling with ice

4: dmap / tetrahydrofuran / 0.08 h / 0 °C / Inert atmosphere

With 4-methyl-morpholine; pyridine; dmap; sodium azide; N-benzyl-N,N,N-triethylammonium chloride; iodine; sodium methylate; triphenylphosphine; In tetrahydrofuran; methanol; acetonitrile;

Reference yield:

: 1145869-41-5
1-((2R,3S,4S,5S)-4-fluoro-3-hydroxy-5-iodomethyl-tetrahydro-furan-2-yl)-1H-pyrimidine-2,4-dione

: 1444430-74-3
benzoic acid (2R,3S,4S,5S)-5-azido-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-fluoro-5-iodomethyl-tetrahydro-furan-3-yl esterine-2,4-dione

Guidance literature:: Multi-step reaction with 3 steps

1: sodium methylate / methanol / 2 h / Reflux

2: N-benzyl-N,N,N-triethylammonium chloride; sodium azide; 4-methyl-morpholine; iodine / acetonitrile; tetrahydrofuran / 0 - 9 °C / Cooling with ice

3: dmap / tetrahydrofuran / 0.08 h / 0 °C / Inert atmosphere

With 4-methyl-morpholine; dmap; sodium azide; N-benzyl-N,N,N-triethylammonium chloride; iodine; sodium methylate; In tetrahydrofuran; methanol; acetonitrile;