benzoic acid (2R,3S,4S,5S)-5-azido-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-fluoro-5-benzoylmethyl-tetrahydro-furan-3-yl esterine-2,4-dione

Base Information

Chemical Name:benzoic acid (2R,3S,4S,5S)-5-azido-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-fluoro-5-benzoylmethyl-tetrahydro-furan-3-yl esterine-2,4-dione
CAS No.:1444430-76-5
Molecular Formula:C₂₃H₁₈FN₅O₇
Molecular Weight:495.424
Hs Code.:

Synonyms:benzoic acid (2R,3S,4S,5S)-5-azido-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-fluoro-5-benzoylmethyl-tetrahydro-furan-3-yl esterine-2,4-dione

Suppliers and Price of benzoic acid (2R,3S,4S,5S)-5-azido-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-fluoro-5-benzoylmethyl-tetrahydro-furan-3-yl esterine-2,4-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of benzoic acid (2R,3S,4S,5S)-5-azido-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-fluoro-5-benzoylmethyl-tetrahydro-furan-3-yl esterine-2,4-dione

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of benzoic acid (2R,3S,4S,5S)-5-azido-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-fluoro-5-benzoylmethyl-tetrahydro-furan-3-yl esterine-2,4-dione

There total 5 articles about benzoic acid (2R,3S,4S,5S)-5-azido-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-fluoro-5-benzoylmethyl-tetrahydro-furan-3-yl esterine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 532-32-1
sodium benzoate

: 1444430-74-3
benzoic acid (2R,3S,4S,5S)-5-azido-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-fluoro-5-iodomethyl-tetrahydro-furan-3-yl esterine-2,4-dione

: 1444430-76-5
benzoic acid (2R,3S,4S,5S)-5-azido-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-fluoro-5-benzoylmethyl-tetrahydro-furan-3-yl esterine-2,4-dione

Guidance literature:: With 18-crown-6 ether; In dimethyl sulfoxide; at 100 ℃; for 18h;

Reference yield:

: 57944-13-5
3'-fluoro-3'-desoxyuridine

: 1444430-76-5
benzoic acid (2R,3S,4S,5S)-5-azido-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-fluoro-5-benzoylmethyl-tetrahydro-furan-3-yl esterine-2,4-dione

Guidance literature:: Multi-step reaction with 5 steps

1: triphenylphosphine; pyridine; iodine / acetonitrile / 12 h / 20 °C / Inert atmosphere

2: sodium methylate / methanol / 2 h / Reflux

3: N-benzyl-N,N,N-triethylammonium chloride; sodium azide; 4-methyl-morpholine; iodine / acetonitrile; tetrahydrofuran / 0 - 9 °C / Cooling with ice

4: dmap / tetrahydrofuran / 0.08 h / 0 °C / Inert atmosphere

5: 18-crown-6 ether / dimethyl sulfoxide / 18 h / 100 °C

With 4-methyl-morpholine; pyridine; dmap; sodium azide; 18-crown-6 ether; N-benzyl-N,N,N-triethylammonium chloride; iodine; sodium methylate; triphenylphosphine; In tetrahydrofuran; methanol; dimethyl sulfoxide; acetonitrile;

Reference yield:

: 1145869-43-7
1-((2R,3S,4S,5S)-5-azido-4-fluoro-3-hydroxy-5-iodomethyl-tetrahydro-furan-2-yl)-1H-pyrimidine-2,4-dione

: 1444430-76-5
benzoic acid (2R,3S,4S,5S)-5-azido-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-fluoro-5-benzoylmethyl-tetrahydro-furan-3-yl esterine-2,4-dione

Guidance literature:: Multi-step reaction with 2 steps

1: dmap / tetrahydrofuran / 0.08 h / 0 °C / Inert atmosphere

2: 18-crown-6 ether / dimethyl sulfoxide / 18 h / 100 °C

With dmap; 18-crown-6 ether; In tetrahydrofuran; dimethyl sulfoxide;