benzoic acid (2R,3S,4S,5R)-2-(2-acetylamino-6-oxo-1,6-dihydro-purin-9-yl)-5-azido-4-fluoro-5-benzoylmethyl-tetrahydro-furan-3-yl ester

Base Information

Chemical Name:benzoic acid (2R,3S,4S,5R)-2-(2-acetylamino-6-oxo-1,6-dihydro-purin-9-yl)-5-azido-4-fluoro-5-benzoylmethyl-tetrahydro-furan-3-yl ester
CAS No.:1444430-79-8
Molecular Formula:C₂₆H₂₁FN₈O₇
Molecular Weight:576.501
Hs Code.:

Synonyms:benzoic acid (2R,3S,4S,5R)-2-(2-acetylamino-6-oxo-1,6-dihydro-purin-9-yl)-5-azido-4-fluoro-5-benzoylmethyl-tetrahydro-furan-3-yl ester

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Chemical Property of benzoic acid (2R,3S,4S,5R)-2-(2-acetylamino-6-oxo-1,6-dihydro-purin-9-yl)-5-azido-4-fluoro-5-benzoylmethyl-tetrahydro-furan-3-yl ester

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Technology Process of benzoic acid (2R,3S,4S,5R)-2-(2-acetylamino-6-oxo-1,6-dihydro-purin-9-yl)-5-azido-4-fluoro-5-benzoylmethyl-tetrahydro-furan-3-yl ester

There total 6 articles about benzoic acid (2R,3S,4S,5R)-2-(2-acetylamino-6-oxo-1,6-dihydro-purin-9-yl)-5-azido-4-fluoro-5-benzoylmethyl-tetrahydro-furan-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 19962-37-9
N-(6-oxo-6,9-dihydro-1H-purin-2-yl)acetamide

: 1444430-76-5
benzoic acid (2R,3S,4S,5S)-5-azido-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-fluoro-5-benzoylmethyl-tetrahydro-furan-3-yl esterine-2,4-dione

: 1444430-79-8
benzoic acid (2R,3S,4S,5R)-2-(2-acetylamino-6-oxo-1,6-dihydro-purin-9-yl)-5-azido-4-fluoro-5-benzoylmethyl-tetrahydro-furan-3-yl ester

Guidance literature:: N-(6-oxo-6,9-dihydro-1H-purin-2-yl)acetamide; In acetonitrile; at 60 ℃;

benzoic acid (2R,3S,4S,5S)-5-azido-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-fluoro-5-benzoylmethyl-tetrahydro-furan-3-yl esterine-2,4-dione; With trimethylsilyl trifluoromethanesulfonate; In acetonitrile; at 100 ℃; for 1h; Microwave irradiation;

Reference yield:

: 1444430-74-3
benzoic acid (2R,3S,4S,5S)-5-azido-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-fluoro-5-iodomethyl-tetrahydro-furan-3-yl esterine-2,4-dione

: 1444430-79-8
benzoic acid (2R,3S,4S,5R)-2-(2-acetylamino-6-oxo-1,6-dihydro-purin-9-yl)-5-azido-4-fluoro-5-benzoylmethyl-tetrahydro-furan-3-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 18-crown-6 ether / dimethyl sulfoxide / 18 h / 100 °C

2.1: BSA / acetonitrile / 60 °C

2.2: 1 h / 100 °C / Microwave irradiation

With 18-crown-6 ether; In dimethyl sulfoxide; acetonitrile;

Reference yield:

: 57944-13-5
3'-fluoro-3'-desoxyuridine

: 1444430-79-8
benzoic acid (2R,3S,4S,5R)-2-(2-acetylamino-6-oxo-1,6-dihydro-purin-9-yl)-5-azido-4-fluoro-5-benzoylmethyl-tetrahydro-furan-3-yl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: triphenylphosphine; pyridine; iodine / acetonitrile / 12 h / 20 °C / Inert atmosphere

2.1: sodium methylate / methanol / 2 h / Reflux

3.1: N-benzyl-N,N,N-triethylammonium chloride; sodium azide; 4-methyl-morpholine; iodine / acetonitrile; tetrahydrofuran / 0 - 9 °C / Cooling with ice

4.1: dmap / tetrahydrofuran / 0.08 h / 0 °C / Inert atmosphere

5.1: 18-crown-6 ether / dimethyl sulfoxide / 18 h / 100 °C

6.1: BSA / acetonitrile / 60 °C

6.2: 1 h / 100 °C / Microwave irradiation

With 4-methyl-morpholine; pyridine; dmap; sodium azide; 18-crown-6 ether; N-benzyl-N,N,N-triethylammonium chloride; iodine; sodium methylate; triphenylphosphine; In tetrahydrofuran; methanol; dimethyl sulfoxide; acetonitrile;