2,3-diphenyl-1H-indole-5-carboxylic Acid

Base Information

Chemical Name:2,3-diphenyl-1H-indole-5-carboxylic Acid
CAS No.:36729-28-9
Molecular Formula:C₂₁H₁₅NO₂
Molecular Weight:313.356
Hs Code.:
DSSTox Substance ID:DTXSID401274313
Mol file:36729-28-9.mol

Synonyms:2,3-diphenyl-1H-indole-5-carboxylic Acid;Oprea1_367632;36729-28-9;SCHEMBL2284207;WSPPMWBJFMUSTB-UHFFFAOYSA-N;DTXSID401274313

Suppliers and Price of 2,3-diphenyl-1H-indole-5-carboxylic Acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2,3-diphenyl-1H-indole-5-carboxylic Acid

Chemical Property:

XLogP3:4.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:313.110278721
Heavy Atom Count:24
Complexity:439

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC=C(C=C1)C2=C(NC3=C2C=C(C=C3)C(=O)O)C4=CC=CC=C4

Technology Process of 2,3-diphenyl-1H-indole-5-carboxylic Acid

There total 5 articles about 2,3-diphenyl-1H-indole-5-carboxylic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 24589-77-3,52455-33-1
4-hydrazinobenzoic acid hydrochloride

: 501-65-5
diphenyl acetylene

: 36729-28-9
2,3-diphenyl-1H-indole-5-carboxylic acid

Guidance literature:: With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; sodium acetate; acetic acid; pentan-3-one; In ethanol; at 110 ℃; for 20h; regioselective reaction; Sealed tube; Inert atmosphere;
DOI:10.1002/adsc.201400224

Reference yield: 75.0%

: 451-40-1
phenyl benzyl ketone

: 619-67-0
4-Hydrazinobenzoic acid

: 36729-28-9
2,3-diphenyl-1H-indole-5-carboxylic acid

Guidance literature:: With hydrogenchloride; sulfuric acid; In water; for 3h; Reflux;

Reference yield:

: 150-13-0,159246-81-8,8014-65-1
4-amino-benzoic acid

: 36729-28-9
2,3-diphenyl-1H-indole-5-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride; sodium nitrite / water / 1 h / 0 - 5 °C / Cooling with ice

1.2: 0 - 20 °C

2.1: pentan-3-one; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; sodium acetate; acetic acid / ethanol / 20 h / 110 °C / Sealed tube; Inert atmosphere

With hydrogenchloride; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; sodium acetate; acetic acid; pentan-3-one; sodium nitrite; In ethanol; water;
DOI:10.1002/adsc.201400224