2-IODO-4,6-DIMETHYLACETANILIDE

Base Information

• Chemical Name: 2-IODO-4,6-DIMETHYLACETANILIDE
• CAS No.: 208659-17-0
• Molecular Formula: C10H12INO
• Molecular Weight: 289.116
• Mol file: 208659-17-0.mol

Synonyms:N-(2-IODO-4,6-DIMETHYLPHENYL)ACETAMIDE;N-(4,6-DIMETHYL-2-IODO-PHENYL)ACETAMIDE;4,6-DIMETHYL-2-IODO-ACETANILIDE;2-IODO-4,6-DIMETHYLACETANILIDE

Chemical Property of 2-IODO-4,6-DIMETHYLACETANILIDE

Chemical Property:

• PSA: 29.10000
• LogP: 2.93940

Purity/Quality:

97% ^*data from raw suppliers

2-IODO-4,6-DIMETHYLACETANILIDE 98.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-IODO-4,6-DIMETHYLACETANILIDE

There total 4 articles about 2-IODO-4,6-DIMETHYLACETANILIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

2-iodo-4,6-dimethylaniline (4102-54-9) + acetyl chloride (75-36-5) → N-(2-iodo-4,6-dimethylphenyl) acetamide (208659-17-0)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃;

DOI:10.1016/j.tet.2004.02.064

Reference yield: 56.0%

N-(2,4-dimethylphenyl)acetamide (2050-43-3) → N-(2-iodo-4,6-dimethylphenyl) acetamide (208659-17-0)

Guidance literature:

With sodium tungstate; sulfuric acid; dihydrogen peroxide; acetic acid; potassium iodide; at 50 ℃; for 1h;

DOI:10.1039/a707933h

Reference yield:

2-iodo-4,6-dimethylaniline (4102-54-9) + acetic anhydride (108-24-7) → N-(2-iodo-4,6-dimethylphenyl) acetamide (208659-17-0)

Guidance literature:

upstream raw materials:

2-iodo-4,6-dimethylaniline

acetic anhydride

N-(2,4-dimethylphenyl)acetamide

acetyl chloride

Downstream raw materials:

N-(2-iodo-4,6-dimethylphenyl)-N-methyl acetamide

rac-N-(2-iodo-4,6-dimethylphenyl)-N-(3-methylbut-2-enyl)acetamide

2-((N-(2-iodo-4,6-dimethylphenyl)acetamido)methyl)-N-methyl-N-phenylacrylamide

Refernces

• 1、 Tasker, Sarah Z.,Jamison, Timothy F.. "Highly regioselective indoline synthesis under nickel/photoredox dual catalysis". supporting information. p. 9531 - 9534. Retrieved 2015/08/18.
• 2、 Ates,Curran. "Synthesis of enantioenriched axially chiral anilides from atropisomerically enriched tartarate ortho-anilides". . p. 5130 - 5131. Retrieved 2007/10/03.