5-IODO-2-METHOXYBENZENEACETIC ACID METHYL ESTER

Base Information

• Chemical Name: 5-IODO-2-METHOXYBENZENEACETIC ACID METHYL ESTER
• CAS No.: 294860-95-0
• Molecular Formula: C₁₀H₁₁IO₃
• Molecular Weight: 306.1
• Mol file: 294860-95-0.mol

Synonyms:5-IODO-2-METHOXYBENZENEACETIC ACID METHYL ESTER;methyl 2-(5-iodo-2-methoxyphenyl)acetate

Chemical Property of 5-IODO-2-METHOXYBENZENEACETIC ACID METHYL ESTER

Chemical Property:

• PSA: 0.00000
• LogP: 0.00000

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-IODO-2-METHOXYBENZENEACETIC ACID METHYL ESTER

There total 3 articles about 5-IODO-2-METHOXYBENZENEACETIC ACID METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

methyl 2-(2-methoxyphenyl)acetate (27798-60-3) → methyl (5-iodo-2-methoxyphenyl)acetate (294860-95-0)

Guidance literature:

With iodine; Selectfluor; In acetonitrile; at 20 ℃; for 4h; Inert atmosphere; Schlenk technique;

DOI:10.1002/ejoc.202101278

Reference yield:

2-methoxyphenylacetic acid (93-25-4) → methyl (5-iodo-2-methoxyphenyl)acetate (294860-95-0) + 5-iodo-2-methoxyphenylaceitc acid

Guidance literature:

With Iodine monochloride; sodium thiosulfate; In 1,4-dioxane; water;

Reference yield:

2-Hydroxyphenylacetic acid (614-75-5) → methyl (5-iodo-2-methoxyphenyl)acetate (294860-95-0)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / acetonitrile / 24 h / Reflux

2: Selectfluor; iodine / acetonitrile / 4 h / 20 °C / Inert atmosphere; Schlenk technique

With iodine; potassium carbonate; Selectfluor; In acetonitrile;

DOI:10.1002/ejoc.202101278

upstream raw materials:

2-methoxyphenylacetic acid

methyl 2-(2-methoxyphenyl)acetate

2-Hydroxyphenylacetic acid