(S)-ethyl 3-(4-(2,7-naphthyridin-1-ylaMino)phenyl)-2-(3-oxospiro[3.5]non-1-en-1-ylaMino)propanoate

Base Information

• Chemical Name: (S)-ethyl 3-(4-(2,7-naphthyridin-1-ylaMino)phenyl)-2-(3-oxospiro[3.5]non-1-en-1-ylaMino)propanoate
• CAS No.: 455264-29-6
• Molecular Formula: C₂₈H₃₀N₄O₃
• Molecular Weight: 470.571
• Mol file: 455264-29-6.mol

Synonyms:(S)-ethyl 3-(4-(2,7-naphthyridin-1-ylaMino)phenyl)-2-(3-oxospiro[3.5]non-1-en-1-ylaMino)propanoate

Chemical Property of (S)-ethyl 3-(4-(2,7-naphthyridin-1-ylaMino)phenyl)-2-(3-oxospiro[3.5]non-1-en-1-ylaMino)propanoate

Chemical Property:

• PSA: 93.21000
• LogP: 5.31820

Purity/Quality:

≥95% ^*data from raw suppliers

(S)-ethyl3-(4-(2,7-naphthyridin-1-ylamino)phenyl)-2-(3-oxospiro[3.5]non-1-en-1-ylamino)propanoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-ethyl 3-(4-(2,7-naphthyridin-1-ylaMino)phenyl)-2-(3-oxospiro[3.5]non-1-en-1-ylaMino)propanoate

There total 4 articles about (S)-ethyl 3-(4-(2,7-naphthyridin-1-ylaMino)phenyl)-2-(3-oxospiro[3.5]non-1-en-1-ylaMino)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.4%

1-chloro-[2,7]naphthyridine (69042-30-4) + (S)-3-(4-amino-phenyl)-2-(3-oxo-spiro[3.5]non-1-en-1-ylamino)-propionic acid ethyl ester (644995-09-5) → UC(933)B1194 (455264-29-6)

Guidance literature:

In ethanol; at 60 ℃; for 4h;

Reference yield: 73.0%

1-keto-3-hydroxyspiro[3.5]-non-2-ene (15546-27-7) + ethyl-(2S)-2-amino-3-[4-([2,7]naphthyridin-1-ylamino)phenyl]propanoate (369648-61-3) → UC(933)B1194 (455264-29-6)

Guidance literature:

In dichloromethane; at 20 ℃; for 24h;

Reference yield: 73.0%

→ UC(933)B1194 (455264-29-6)

Guidance literature:

upstream raw materials:

1-keto-3-hydroxyspiro[3.5]-non-2-ene

ethyl-(2S)-2-amino-3-[4-([2,7]naphthyridin-1-ylamino)phenyl]propanoate

1-chloro-[2,7]naphthyridine

(S)-3-(4-amino-phenyl)-2-(3-oxo-spiro[3.5]non-1-en-1-ylamino)-propionic acid ethyl ester

Downstream raw materials:

zaurategrast ethyl

UC⁽⁹¹¹⁾B₁₁₃₃