1-(4-chloro-1,2,5-thiadiazol-3-yl)-4-methylpiperazine(SALTDATA: HCl)

Base Information

• Chemical Name: 1-(4-chloro-1,2,5-thiadiazol-3-yl)-4-methylpiperazine(SALTDATA: HCl)
• CAS No.: 870987-89-6
• Molecular Formula: C7H11ClN4S
• Molecular Weight: 218.70704
• Hs Code.: 2934999090
• Mol file: 870987-89-6.mol

Synonyms:1-(4-chloro-1,2,5-thiadiazol-3-yl)-4-methylpiperazine(SALTDATA: HCl);3-chloro-4-(4-methylpiperazin-1-yl)-1,2,5-thiadiazole

Chemical Property of 1-(4-chloro-1,2,5-thiadiazol-3-yl)-4-methylpiperazine(SALTDATA: HCl)

Chemical Property:

• PSA: 60.50000
• LogP: 0.94620

Purity/Quality:

98%min ^*data from raw suppliers

1-(4-chloro-1,2,5-thiadiazol-3-yl)-4-methylpiperazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(4-chloro-1,2,5-thiadiazol-3-yl)-4-methylpiperazine(SALTDATA: HCl)

There total 2 articles about 1-(4-chloro-1,2,5-thiadiazol-3-yl)-4-methylpiperazine(SALTDATA: HCl) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

1-methyl-piperazine (109-01-3) + 3,4-dichloro-1,2,5-thiadiazole (5728-20-1) → 3-chloro-4-(4-methylpiperazin-1-yl)-1,2,5-thiadiazole (870987-89-6)

Guidance literature:

In ethanol; at 100 ℃; for 2.5h; Sealed tube; Microwave irradiation;

DOI:10.1021/acsinfecdis.7b00212

Reference yield:

→ 3-chloro-4-(4-methylpiperazin-1-yl)-1,2,5-thiadiazole (870987-89-6)

Guidance literature:

Reference yield: 51.0%

formic acid (64-18-6) + 3-chloro-4-(4-methylpiperazin-1-yl)-1,2,5-thiadiazole (870987-89-6) + N-(3-chloro-4-((3-fluorobenzyl)oxy)phenyl)-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)quinolin-4-amine → N-(3-chloro-4-((3-fluorobenzyl)oxy)phenyl)-7-(4-(4-methylpiperazin-1-yl)-1,2,5-thiadiazol-3-yl)quinolin-4-amine formate

Guidance literature:

3-chloro-4-(4-methylpiperazin-1-yl)-1,2,5-thiadiazole; N-(3-chloro-4-((3-fluorobenzyl)oxy)phenyl)-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)quinolin-4-amine; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; water; at 120 ℃; for 2h; Microwave irradiation; Sealed tube; Inert atmosphere;

formic acid;

DOI:10.1021/acsinfecdis.7b00212

upstream raw materials:

1-methyl-piperazine

3,4-dichloro-1,2,5-thiadiazole

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