N-(3-Chloro-4-fluorophenyl)-6-nitro-7-(phenylsulfonyl)-4-quinazolinaMine

Base Information

• Chemical Name: N-(3-Chloro-4-fluorophenyl)-6-nitro-7-(phenylsulfonyl)-4-quinazolinaMine
• CAS No.: 945553-94-6
• Molecular Formula: C20H12ClFN4O4S
• Molecular Weight: 458.857
• Mol file: 945553-94-6.mol

Synonyms:N-(3-Chloro-4-fluorophenyl)-6-nitro-7-(phenylsulfonyl)-4-quinazolinaMine;7-(benzenesulfonyl)-N-(3-chloro-4-fluorophenyl)-6-nitroquinazolin-4-amine;(7-Benzenesulfonyl-6-nitro-quinazolin-4-yl)-(3-chloro-4-fluoro-phenyl)-amine

Chemical Property of N-(3-Chloro-4-fluorophenyl)-6-nitro-7-(phenylsulfonyl)-4-quinazolinaMine

Chemical Property:

• PSA: 126.15000
• LogP: 6.58390

Purity/Quality:

99.9% ^*data from raw suppliers

N-(3-Chloro-4-fluorophenyl)-6-nitro-7-(phenylsulfonyl)quinazolin-4-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: N-(3-Chloro-4-fluorophenyl)-6-nitro-7-(phenylsulfonyl)quinazolin-4-amine is used in the preparation of novel 4-anilinoquinzaolines which act as inhibitors of epidermal growth factor receptor.

Technology Process of N-(3-Chloro-4-fluorophenyl)-6-nitro-7-(phenylsulfonyl)-4-quinazolinaMine

There total 8 articles about N-(3-Chloro-4-fluorophenyl)-6-nitro-7-(phenylsulfonyl)-4-quinazolinaMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.2%

7-chloro-N-(3-chloro-4-fluorophenyl)-6-nitroquinazolin-4-amine (179552-73-9) + sodium benzenesulfonate (873-55-2) → N-((3-chloro-4-fluorophenyl)-6-nitro-7-phenylsulfonyl)quinazolin-4-one (945553-94-6)

Guidance literature:

In N,N-dimethyl-formamide; at 20 - 90 ℃; for 6h;

Reference yield:

7-chloro-N-(3-chloro-4-fluorophenyl)-6-nitroquinazolin-4-amine (179552-73-9) + Benzenesulfinic acid (618-41-7) → N-((3-chloro-4-fluorophenyl)-6-nitro-7-phenylsulfonyl)quinazolin-4-one (945553-94-6)

Guidance literature:

In N,N-dimethyl-formamide; at 90 ℃; for 2h;

Reference yield:

7-chloro-6-nitro-4(3H)-quinazolinone (53449-14-2) → N-((3-chloro-4-fluorophenyl)-6-nitro-7-phenylsulfonyl)quinazolin-4-one (945553-94-6)

Guidance literature:

Multi-step reaction with 3 steps

1: trichlorophosphate / 2 h / 90 °C

2: 1,4-dioxane / 3 h / 90 °C

3: 2 h / 90 °C

With trichlorophosphate; In 1,4-dioxane;

DOI:10.1016/j.bmc.2013.09.049

upstream raw materials:

7-chloro-N-(3-chloro-4-fluorophenyl)-6-nitroquinazolin-4-amine

sodium benzenesulfonate

sodium phenylsulfonate

7-chloro-3,4-dihydroquinazolin-4-one

Downstream raw materials:

4-[(3-chloro-4-fluorophenyl)amino]-6-nitro-7-[(S)-(tetrahydrofuran-3-yl)oxy]quinazoline

6-Amino-4-[(3-chloro-4-fluorophenyl)amino]-7-[(S)-(tetrahydrofuran-3-yl)oxy]quinazoline