Ethyl 3-aMino-6-chloropyridine-2-carboxylate

Base Information

• Chemical Name: Ethyl 3-aMino-6-chloropyridine-2-carboxylate
• CAS No.: 1352200-86-2
• Molecular Formula: C8H9ClN2O2
• Molecular Weight: 200.62226
• Mol file: 1352200-86-2.mol

Synonyms:Ethyl 3-aMino-6-chloropyridine-2-carboxylate;methyl 3-amino-6-chloropyridine-2-carboxylate;Ethyl 3-amino-6-chloropicolinate

Chemical Property of Ethyl 3-aMino-6-chloropyridine-2-carboxylate

Chemical Property:

• Boiling Point: 371.3±37.0 °C(Predicted)
• PKA: 0.07±0.10(Predicted)
• PSA: 65.21000
• Density: 1.326±0.06 g/cm3(Predicted)
• LogP: 2.07510

Purity/Quality:

NLT 98% ^*data from raw suppliers

Ethyl3-Amino-6-chloropyridine-2-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl 3-aMino-6-chloropyridine-2-carboxylate

There total 1 articles about Ethyl 3-aMino-6-chloropyridine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

ethanol (64-17-5) + carbon monoxide (201230-82-2) + 2-bromo-6-chloro-pyridin-3-amine (1050501-88-6) → 3-amino-6-chloro-pyridine-2-carboxylic acid ethyl ester (1352200-86-2)

Guidance literature:

With triethylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In toluene; at 80 ℃; for 16h; under 37503.8 Torr; Inert atmosphere; autoclave;

upstream raw materials:

ethanol

carbon monoxide

2-bromo-6-chloro-pyridin-3-amine

Refernces

• 1、 -. "NITROGEN CONTAINING HETEROARYL COMPOUNDS". Page/Page column 223. . Retrieved 2012/01/04.