methyl (R)-2-amino-3-(4-bromophenyl)propanoate hydrochloride

Base Information

• Chemical Name: methyl (R)-2-amino-3-(4-bromophenyl)propanoate hydrochloride
• CAS No.: 459133-43-8
• Molecular Formula: C₁₀H₁₂BrNO₂*ClH
• Molecular Weight: 294.576
• Mol file: 459133-43-8.mol

Synonyms:methyl (R)-2-amino-3-(4-bromophenyl)propanoate hydrochloride

Chemical Property of methyl (R)-2-amino-3-(4-bromophenyl)propanoate hydrochloride

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl (R)-2-amino-3-(4-bromophenyl)propanoate hydrochloride

There total 2 articles about methyl (R)-2-amino-3-(4-bromophenyl)propanoate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

→ (R)-2-amino-3-(4-bromophenyl)propionic acid methyl ester hydrochloride (459133-43-8,99359-32-7)

Guidance literature:

With thionyl chloride; for 2h; Reflux;

Reference yield:

methanol (67-56-1) + (2R)-2-amino-3-(4-bromophenyl)propanoic acid (62561-74-4) → (R)-2-amino-3-(4-bromophenyl)propionic acid methyl ester hydrochloride (459133-43-8,99359-32-7)

Guidance literature:

With thionyl chloride; at 0 - 20 ℃;

DOI:10.1021/acs.orglett.9b02819

Reference yield: 80.0%

di-tert-butyl dicarbonate (24424-99-5) + (R)-2-amino-3-(4-bromophenyl)propionic acid methyl ester hydrochloride (459133-43-8,99359-32-7) → methyl (R)-3-(4-bromophenyl)-2-((tert-butoxycarbonyl)amino)propanoate (1213855-60-7)

Guidance literature:

With triethylamine; In dichloromethane; at 20 - 25 ℃; for 3h;

upstream raw materials:

methanol

(2R)-2-amino-3-(4-bromophenyl)propanoic acid

Downstream raw materials:

C₁₃H₁₆BrNO₄

methyl (R)-α-<<(1,1-dimethylethoxy)carbonyl>amino><1,1'-biphenyl>-4-propanoate

N-[(1R)-2-[1,1'-biphenyl]-4-yl-1-(hydroxymethyl)ethyl]carbamic acid tert-butyl ester

methyl (R)-3-(4-bromophenyl)-2-((tert-butoxycarbonyl)amino)propanoate