Boc-Glu(Osu)-Otbu

Base Information

• Chemical Name: Boc-Glu(Osu)-Otbu
• CAS No.: 81659-82-7
• Molecular Formula: C18H28N2O8
• Molecular Weight: 400.42
• DSSTox Substance ID: DTXSID30562666
• Wikidata: Q82446917
• Mol file: 81659-82-7.mol

Synonyms:Boc-Glu(Osu)-Otbu;81659-82-7;1-O-tert-butyl 5-O-(2,5-dioxopyrrolidin-1-yl) (2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]pentanedioate;Boc-L-Glu(OSu)-OtBu;MFCD00236848;SCHEMBL16923606;DTXSID30562666;AKOS015999064;Boc-L-glutamic acid gamma-N-hydroxysuccinimide ester alpha-tert-butyl ester;FD21415;AS-49063;CS-0137337;A864509;A1-57634;(S)-1-tert-Butyl 5-(2,5-dioxopyrrolidin-1-yl) 2-((tert-butoxycarbonyl)amino)pentanedioate;1-(tert-butyl) 5-(2,5-dioxopyrrolidin-1-yl) (tert-butoxycarbonyl)-l-glutamate;1-tert-Butyl 5-(2,5-dioxopyrrolidin-1-yl) N-(tert-butoxycarbonyl)-L-glutamate;Boc-L-glutamic acid gamma -N-hydroxysuccinimide ester alpha -tert-butyl ester

Chemical Property of Boc-Glu(Osu)-Otbu

Chemical Property:

• PSA: 128.31000
• LogP: 1.93760
• Storage Temp.: -15°C
• Solubility.: Chloroform (Slightly)
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 11
• Exact Mass: 400.18456586
• Heavy Atom Count: 28
• Complexity: 629

Purity/Quality:

97% ^*data from raw suppliers

Boc-L-glutamic acid γ-N-hydroxysuccinimide ester alpha-tert-butyl ester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)C(CCC(=O)ON1C(=O)CCC1=O)NC(=O)OC(C)(C)C
• Isomeric SMILES: CC(C)(C)OC(=O)[C@H](CCC(=O)ON1C(=O)CCC1=O)NC(=O)OC(C)(C)C

Technology Process of Boc-Glu(Osu)-Otbu

There total 1 articles about Boc-Glu(Osu)-Otbu which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + N-tert-butoxycarbonyl glutamic acid tert-butyl ester (24277-39-2) → N-α-tert-butoxycarbonyl-L-glutamic acid γ-N-succinimidyl ester α-tert-butyl ester (81659-82-7)

Guidance literature:

With dicyclohexyl-carbodiimide; In diethyl ether; at 20 ℃; for 24h; Temperature; Time;

Reference yield: 65.0%

N-α-tert-butoxycarbonyl-L-glutamic acid γ-N-succinimidyl ester α-tert-butyl ester (81659-82-7) + (R)-2-Oxo-thiazolidine-4-carboxylic acid 2-oxo-2-phenyl-ethyl ester → 2-oxo-3-[α-[N-(tert-butoxycarbonyl)-O-(tert-butyl)]-L-γ-glutamyl]thiazolidine-4(R)-carboxylic acid phenacyl ester (255057-31-9)

Guidance literature:

With dmap; triethylamine; at 50 ℃; for 48h;

DOI:10.1021/jm980289j

Reference yield:

mob-selenocysteine + N-α-tert-butoxycarbonyl-L-glutamic acid γ-N-succinimidyl ester α-tert-butyl ester (81659-82-7) → boc-Glu(OtBu)-Se(mob)CysOH

Guidance literature:

With triethylamine; In 1,4-dioxane; water; at 22 ℃; for 50h;

upstream raw materials:

1-hydroxy-pyrrolidine-2,5-dione

N-tert-butoxycarbonyl glutamic acid tert-butyl ester

Downstream raw materials:

2-oxo-3-[α-[N-(tert-butoxycarbonyl)-O-(tert-butyl)]-L-γ-glutamyl]thiazolidine-4(R)-carboxylic acid phenacyl ester

trypanothione disulfide

N¹-Mono-glutathionylspermidine