1-(5-Iodothiophen-2-yl)propan-1-one

Base Information

• Chemical Name: 1-(5-Iodothiophen-2-yl)propan-1-one
• CAS No.: 23757-10-0
• Molecular Formula: C₇H₇IOS
• Molecular Weight: 266.102
• DSSTox Substance ID: DTXSID90695101
• Wikidata: Q82624122
• Mol file: 23757-10-0.mol

Synonyms:1-(5-iodothiophen-2-yl)propan-1-one;23757-10-0;SCHEMBL660893;DTXSID90695101;AKAOMSFPCWJXKK-UHFFFAOYSA-N;tert-butyl 2-(4-(methoxycarbonyl)piperidin-1-yl)nicotinate

Chemical Property of 1-(5-Iodothiophen-2-yl)propan-1-one

Chemical Property:

• PSA: 45.31000
• LogP: 2.94540
• XLogP3: 2.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 265.92623
• Heavy Atom Count: 10
• Complexity: 138

Purity/Quality:

99% ^*data from raw suppliers

1-(5-iodothiophen-2-yl)propan1-one 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC(=O)C1=CC=C(S1)I

Technology Process of 1-(5-Iodothiophen-2-yl)propan-1-one

There total 2 articles about 1-(5-Iodothiophen-2-yl)propan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

2-Iodothiophene (3437-95-4,149762-92-5) + N-methyl-N-methoxypropionamide (104863-65-2) → 1-(5-iodothiophen-2-yl)propan-1-one (23757-10-0)

Guidance literature:

2-Iodothiophene; With lithium diisopropyl amide; In tetrahydrofuran; n-heptane; ethylbenzene; at -40 - -10 ℃; for 0.666667h; Inert atmosphere;

N-methyl-N-methoxypropionamide; In tetrahydrofuran; n-heptane; ethylbenzene; at -40 - 0 ℃; Inert atmosphere;

With water; ammonium chloride; In tetrahydrofuran; n-heptane; ethylbenzene; at 0 ℃;

Reference yield: 33.0%

2-Iodothiophene (3437-95-4,149762-92-5) + propionic acid anhydride (123-62-6) → 1-(5-iodothiophen-2-yl)propan-1-one (23757-10-0)

Guidance literature:

With boron trifluoride diethyl etherate; at 100 ℃; for 1h; Inert atmosphere;

DOI:10.1002/chem.201500658

Reference yield:

1-(5-iodothiophen-2-yl)propan-1-one (23757-10-0) + 2,4-dichlorophenyl hydrazine hydrochloride (5446-18-4) + oxalic acid diethyl ester (95-92-1) → ethyl 1-(2,4-dichlorophenyl)-5-(5-iodothiophen-2-yl)-4-methyl-1H-pyrazole-3-carboxylate (1160842-69-2)

Guidance literature:

1-(5-iodothiophen-2-yl)propan-1-one; oxalic acid diethyl ester; With lithium hexamethyldisilazane; In tetrahydrofuran; diethyl ether; at -78 ℃;

2,4-dichlorophenyl hydrazine hydrochloride; In ethanol; at 0 - 5 ℃; for 1h;

With hydrogenchloride; In isopropyl alcohol; at 75 - 78 ℃;

DOI:10.1016/j.bmcl.2009.03.046

upstream raw materials:

2-Iodothiophene

propionic acid anhydride

N-methyl-N-methoxypropionamide

Downstream raw materials:

ethyl 1-(2,4-dichlorophenyl)-5-(5-iodothiophen-2-yl)-4-methyl-1H-pyrazole-3-carboxylate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 23757-10-0 1-(5-IODO-THIOPHEN-2-YL)-PROPAN-1-ONE

Send

Send

Metric Ton KG G Pound L ML

Send

Send