Ethanone, 1-[5-(1-Methylethyl)-2,4-bis(phenylMethoxy)phenyl]-

Base Information

• Chemical Name: Ethanone, 1-[5-(1-Methylethyl)-2,4-bis(phenylMethoxy)phenyl]-
• CAS No.: 747414-18-2
• Molecular Formula: C25H26O3
• Molecular Weight: 374.48
• Hs Code.: 2914509090
• Mol file: 747414-18-2.mol

Synonyms:Ethanone, 1-[5-(1-Methylethyl)-2,4-bis(phenylMethoxy)phenyl]-;1-(2,4-bis(benzyloxy)-5-isopropylphenyl)ethanone

Chemical Property of Ethanone, 1-[5-(1-Methylethyl)-2,4-bis(phenylMethoxy)phenyl]-

Chemical Property:

• PSA: 35.53000
• LogP: 6.17060

Purity/Quality:

97% ^*data from raw suppliers

1-(2,4-Bis(benzyloxy)-5-isopropylphenyl)ethanone 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethanone, 1-[5-(1-Methylethyl)-2,4-bis(phenylMethoxy)phenyl]-

There total 5 articles about Ethanone, 1-[5-(1-Methylethyl)-2,4-bis(phenylMethoxy)phenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1-(2,4-dihydroxy-5-isopropylphenyl)ethan-1-one (747414-17-1) + benzyl bromide (100-39-0) → 1-(2,4-bis(benzyloxy)-5-isopropylphenyl)ethan-1-one (747414-18-2)

Guidance literature:

With potassium carbonate; In acetonitrile; at 20 ℃;

DOI:10.1016/j.bmcl.2015.06.009

Reference yield:

2,4-dihydroxy-1-isopropylbenzene (23504-03-2) → 1-(2,4-bis(benzyloxy)-5-isopropylphenyl)ethan-1-one (747414-18-2)

Guidance literature:

Multi-step reaction with 2 steps

1: boron trifluoride diethyl etherate / 3 h / Reflux

2: potassium carbonate / acetone / 4 h / Reflux

With boron trifluoride diethyl etherate; potassium carbonate; In acetone;

DOI:10.1002/minf.201300182

Reference yield:

2,4-bis(benzyloxy)acetophenone (22877-01-6) → 1-(2,4-bis(benzyloxy)-5-isopropylphenyl)ethan-1-one (747414-18-2)

Guidance literature:

Multi-step reaction with 4 steps

1: triphenylmethylphosphonium bromide; potassium tert-butylate / tetrahydrofuran / 1 h / 0 - 25 °C

2: palladium on activated charcoal; hydrogen / tetrahydrofuran / 12 h / 20 °C

3: boron trifluoride diethyl etherate / 3 h / Reflux

4: potassium carbonate / acetone / 4 h / Reflux

With triphenylmethylphosphonium bromide; palladium on activated charcoal; boron trifluoride diethyl etherate; potassium tert-butylate; hydrogen; potassium carbonate; In tetrahydrofuran; acetone;

DOI:10.1002/minf.201300182

upstream raw materials:

1-(2,4-dihydroxy-5-isopropylphenyl)ethan-1-one

benzyl bromide

2',4'-dihydroxy-4-acetophenone

(((4-(prop-1-en-2-yl)-1,3-phenylene)bis(oxy))bis(methylene))dibenzene

Downstream raw materials:

4-(2,4-bis(benzyloxy)-5-isopropylphenyl)-2-hydroxy-4-oxobut-2-enoic acid ethyl ester

2,4-bis(benzyloxy)-5-(propan-2-yl)benzoic acid