2-BROMO-4'CARBOETHOXYBENZOPHENONE

Base Information

• Chemical Name: 2-BROMO-4'CARBOETHOXYBENZOPHENONE
• CAS No.: 746651-78-5
• Molecular Formula: C₁₆H₁₃BrO₃
• Molecular Weight: 333.181
• Hs Code.: 2914700090
• Mol file: 746651-78-5.mol

Synonyms:2-BROMO-4'CARBOETHOXYBENZOPHENONE

Chemical Property of 2-BROMO-4'CARBOETHOXYBENZOPHENONE

Chemical Property:

• Vapor Pressure: 8.22E-08mmHg at 25°C
• Boiling Point: 436.2°C at 760 mmHg
• Flash Point: 217.6°C
• PSA: 43.37000
• Density: 1.399g/cm³
• LogP: 3.85680

Purity/Quality:

99% ^*data from raw suppliers

2-Bromo-4'carboethoxybenzophenone 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-BROMO-4'CARBOETHOXYBENZOPHENONE

There total 6 articles about 2-BROMO-4'CARBOETHOXYBENZOPHENONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

2-bromophenyl(4-methylphenyl)methanone (67104-64-7) + ethyl iodide (75-03-6) → ethyl 4-(2-bromobenzoyl)benzoate (746651-78-5)

Guidance literature:

2-bromophenyl(4-methylphenyl)methanone; With ammonium cerium (IV) nitrate; nitric acid; for 36h; Reflux;

ethyl iodide; With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 10h;

Reference yield:

C14H9BrO3 + ethyl iodide (75-03-6) → ethyl 4-(2-bromobenzoyl)benzoate (746651-78-5)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 10h;

DOI:10.1002/adsc.201500953

Reference yield:

para-bromotoluene (106-38-7) → ethyl 4-(2-bromobenzoyl)benzoate (746651-78-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: magnesium / tetrahydrofuran / 3 h / Reflux

1.2: 0.5 h / 0 °C

2.1: Dess-Martin periodane / dichloromethane / 1 h / 20 °C

3.1: ammonium cerium (IV) nitrate; nitric acid / 36 h / Reflux

4.1: potassium carbonate / N,N-dimethyl-formamide / 10 h / 20 °C

With ammonium cerium (IV) nitrate; nitric acid; potassium carbonate; Dess-Martin periodane; magnesium; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1002/adsc.201500953

upstream raw materials:

ethyl iodide

ortho-bromobenzaldehyde

para-bromotoluene

(2-bromophenyl)(p-tolyl)methanol