1-benzyl 3-Methyl pyrrolidine-1,3-dicarboxylate

Base Information

• Chemical Name: 1-benzyl 3-Methyl pyrrolidine-1,3-dicarboxylate
• CAS No.: 912444-75-8
• Molecular Formula: C14H17NO4
• Molecular Weight: 263.293
• Mol file: 912444-75-8.mol

Synonyms:3-Methyl-pyrrolidine-1,3-dicarboxylic acid 1-benzyl ester

Chemical Property of 1-benzyl 3-Methyl pyrrolidine-1,3-dicarboxylate

Chemical Property:

• PSA: 66.84000
• LogP: 2.05770

Purity/Quality:

99%, ^*data from raw suppliers

1-Cbz-3-methylpyrrolidine-3-carboxylicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-benzyl 3-Methyl pyrrolidine-1,3-dicarboxylate

There total 9 articles about 1-benzyl 3-Methyl pyrrolidine-1,3-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1-benzyl 3-methyl 3-methylpyrrolidine-1,3-dicarboxylate (912444-74-7) → 1-((benzyloxy)carbonyl)-3-methylpyrrolidine-3-carboxylic acid (912444-75-8,1412254-20-6)

Guidance literature:

1-benzyl 3-methyl 3-methylpyrrolidine-1,3-dicarboxylate; With water; lithium hydroxide; In ethanol; for 1h; Heating;

With potassium hydrogensulfate; In water; pH=3 - 4;

Reference yield: 97.0%

C18H25NO4 (1446482-09-2) → 1-((benzyloxy)carbonyl)-3-methylpyrrolidine-3-carboxylic acid (912444-75-8,1412254-20-6)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 17h;

DOI:10.1021/jo4010316

Reference yield:

pyrrolidine-1,3-dicarboxylic acid 1-benzyl ester 3-methyl ester (188847-00-9,1217655-90-7) → 1-((benzyloxy)carbonyl)-3-methylpyrrolidine-3-carboxylic acid (912444-75-8,1412254-20-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.33 h / -78 °C

1.2: -78 - 20 °C

2.1: water; lithium hydroxide / ethanol / 1 h / Heating

2.2: pH 3 - 4

With water; lithium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol;

upstream raw materials:

1-benzyl 3-methyl 3-methylpyrrolidine-1,3-dicarboxylate

1-tert-butyl 4-ethyl 2-cyano-2-methylbutanedioate

C₁₀H₁₇NO₃

C₁₀H₁₉NO₂

Downstream raw materials:

1-benzyloxycarbonyl-3-(N-tert-butoxycarbonylamino)-3-methylpyrrolidine

3-methylpyrrolidine-3-carboxylic acid

3-tert-butoxycarbonylamino-3-methyl-pyrrolidine

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