Technology Process of 4-(4-amino-2-fluorophenoxy)-3-chloro-N-(diphenylmethylene)-2-Pyridinamine
There total 7 articles about 4-(4-amino-2-fluorophenoxy)-3-chloro-N-(diphenylmethylene)-2-Pyridinamine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen;
In
2-methyltetrahydrofuran;
at 25 ℃;
for 6h;
under 2052.96 Torr;
Reagent/catalyst;
chemoselective reaction;
Inert atmosphere;
Large scale;
DOI:10.1021/op3002239
- Guidance literature:
-
Multi-step reaction with 4 steps
1: palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; caesium carbonate / 2-methyltetrahydrofuran / 18 h / 80 °C / Large scale
2: sodium percarbonate; lithium diisopropyl amide; triisopropylborane / water / 3 h / 0 - 25 °C / Large scale
3: caesium carbonate / N,N-dimethyl-formamide / 1 h / 90 °C / Large scale
4: zinc; ammonium chloride
With
sodium percarbonate; triisopropylborane; palladium diacetate; ammonium chloride; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; zinc; lithium diisopropyl amide;
In
2-methyltetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1021/op3002239
- Guidance literature:
-
Multi-step reaction with 3 steps
1: sodium percarbonate; lithium diisopropyl amide; triisopropylborane / water / 3 h / 0 - 25 °C / Large scale
2: caesium carbonate / N,N-dimethyl-formamide / 1 h / 90 °C / Large scale
3: zinc; ammonium chloride
With
sodium percarbonate; triisopropylborane; ammonium chloride; caesium carbonate; zinc; lithium diisopropyl amide;
In
water; N,N-dimethyl-formamide;
DOI:10.1021/op3002239
