4-(4-amino-2-fluorophenoxy)-3-chloro-N-(diphenylmethylene)-2-Pyridinamine

Base Information

Chemical Name:4-(4-amino-2-fluorophenoxy)-3-chloro-N-(diphenylmethylene)-2-Pyridinamine
CAS No.:1174046-76-4
Molecular Formula:C24H17ClFN3O
Molecular Weight:417.87
Hs Code.:
Mol file:1174046-76-4.mol

Synonyms:4-(4-amino-2-fluorophenoxy)-3-chloro-N-(diphenylmethylene)-2-Pyridinamine;4-((3-chloro-2-((diphenylmethylene)amino)pyridin-4-yl)oxy)-3-fluoroaniline

Suppliers and Price of 4-(4-amino-2-fluorophenoxy)-3-chloro-N-(diphenylmethylene)-2-Pyridinamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 7 raw suppliers

Chemical Property of 4-(4-amino-2-fluorophenoxy)-3-chloro-N-(diphenylmethylene)-2-Pyridinamine

Chemical Property:

Boiling Point:542.1±50.0 °C(Predicted)
PKA:3.42±0.37(Predicted)
PSA：60.50000
Density:1.26±0.1 g/cm3(Predicted)
LogP:6.99890

Purity/Quality:: 98%min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

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Technology Process of 4-(4-amino-2-fluorophenoxy)-3-chloro-N-(diphenylmethylene)-2-Pyridinamine

There total 7 articles about 4-(4-amino-2-fluorophenoxy)-3-chloro-N-(diphenylmethylene)-2-Pyridinamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1174046-75-3
3-chloro-N-(diphenylmethylene)-4-(2-fluoro-4-nitrophenoxy)pyridin-2-amine

: 1174046-76-4
4-(4-amino-2-fluorophenoxy)-3-chloro-N-(diphenylmethylene)pyridin-2-amine

Guidance literature:: With hydrogen; In 2-methyltetrahydrofuran; at 25 ℃; for 6h; under 2052.96 Torr; Reagent/catalyst; chemoselective reaction; Inert atmosphere; Large scale;
DOI:10.1021/op3002239

Reference yield:

: 2402-77-9
2,3-dichloro-pyridine

: 1174046-76-4
4-(4-amino-2-fluorophenoxy)-3-chloro-N-(diphenylmethylene)pyridin-2-amine

Guidance literature:: Multi-step reaction with 4 steps

1: palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; caesium carbonate / 2-methyltetrahydrofuran / 18 h / 80 °C / Large scale

2: sodium percarbonate; lithium diisopropyl amide; triisopropylborane / water / 3 h / 0 - 25 °C / Large scale

3: caesium carbonate / N,N-dimethyl-formamide / 1 h / 90 °C / Large scale

4: zinc; ammonium chloride

With sodium percarbonate; triisopropylborane; palladium diacetate; ammonium chloride; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; zinc; lithium diisopropyl amide; In 2-methyltetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1021/op3002239

Reference yield:

: 1174046-97-9
3-chloro-N-(diphenylmethylene)pyridin-2-amine

: 1174046-76-4
4-(4-amino-2-fluorophenoxy)-3-chloro-N-(diphenylmethylene)pyridin-2-amine

Guidance literature:: Multi-step reaction with 3 steps

1: sodium percarbonate; lithium diisopropyl amide; triisopropylborane / water / 3 h / 0 - 25 °C / Large scale

2: caesium carbonate / N,N-dimethyl-formamide / 1 h / 90 °C / Large scale

3: zinc; ammonium chloride

With sodium percarbonate; triisopropylborane; ammonium chloride; caesium carbonate; zinc; lithium diisopropyl amide; In water; N,N-dimethyl-formamide;
DOI:10.1021/op3002239