2-[(2',6'-DICHLOROPHENYL)AMINO]-5-HYDROXYPHENYL-N,N-DIMETHYLACETAMIDE

Base Information

• Chemical Name: 2-[(2',6'-DICHLOROPHENYL)AMINO]-5-HYDROXYPHENYL-N,N-DIMETHYLACETAMIDE
• CAS No.: 698357-97-0
• Molecular Formula: C16H16Cl2N2O2
• Molecular Weight: 339.221
• Mol file: 698357-97-0.mol

Synonyms:2-[(2',6'-DICHLOROPHENYL)AMINO]-5-HYDROXYPHENYL-N,N-DIMETHYLACETAMIDE;2-[2-(2,6-Dichloro-phenylamino)-5-hydroxy-phenyl]-N,N-dimethylacetamide;2-[(2,6-Dichlorophenyl)aMino]-5-hydroxy-N,N-diMethyl-benzeneacetaMide

Chemical Property of 2-[(2',6'-DICHLOROPHENYL)AMINO]-5-HYDROXYPHENYL-N,N-DIMETHYLACETAMIDE

Chemical Property:

• PSA: 52.57000
• LogP: 4.14630
• Solubility.: Chloroform, Ethyl Acetate, Ethyl Ether,

Purity/Quality:

98%Min ^*data from raw suppliers

2-[(2’,6’-Dichlorophenyl)amino]-5-hydroxyphenyl-N,N-dimethylacetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-[(2’,6’-Dichlorophenyl)amino]-5-hydroxyphenyl-N,N-dimethylacetamide (cas# 698357-97-0) is a compound useful in organic synthesis.

Technology Process of 2-[(2',6'-DICHLOROPHENYL)AMINO]-5-HYDROXYPHENYL-N,N-DIMETHYLACETAMIDE

There total 3 articles about 2-[(2',6'-DICHLOROPHENYL)AMINO]-5-HYDROXYPHENYL-N,N-DIMETHYLACETAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-[(2',6'-dichlorophenyl)amino]-5-methoxyphenyl-N,N-dimethylacetamide (698357-92-5) → 2-[(2',6'-dichlorophenyl)amino]-5-hydroxyphenyl-N,N-dimethylacetamide (698357-97-0)

Guidance literature:

With boron tribromide; In dichloromethane; 1,2-dichloro-ethane; at 20 ℃;

DOI:10.1021/jm030891w

Reference yield:

2-(3-methoxyphenyl)-N,N-dimethylacetamide (90526-08-2) → 2-[(2',6'-dichlorophenyl)amino]-5-hydroxyphenyl-N,N-dimethylacetamide (698357-97-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 80 percent / N-iodosuccinimide / acetonitrile / 12 h / Heating

2: 91 percent / K₂CO₃; CuI; Cu / toluene / 24 h / Heating

3: 90 percent / BBr₃ / CH₂Cl₂; 1,2-dichloro-ethane / 20 °C

With N-iodo-succinimide; copper(l) iodide; boron tribromide; copper; potassium carbonate; In dichloromethane; 1,2-dichloro-ethane; toluene; acetonitrile; 2: Ullmann coupling;

DOI:10.1021/jm030891w

Reference yield:

(6-iodo-3-methoxy)phenyl-N,N-dimethylacetamide (99540-20-2) → 2-[(2',6'-dichlorophenyl)amino]-5-hydroxyphenyl-N,N-dimethylacetamide (698357-97-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / K₂CO₃; CuI; Cu / toluene / 24 h / Heating

2: 90 percent / BBr₃ / CH₂Cl₂; 1,2-dichloro-ethane / 20 °C

With copper(l) iodide; boron tribromide; copper; potassium carbonate; In dichloromethane; 1,2-dichloro-ethane; toluene; 1: Ullmann coupling;

DOI:10.1021/jm030891w

upstream raw materials:

2-[(2',6'-dichlorophenyl)amino]-5-methoxyphenyl-N,N-dimethylacetamide

2-(3-methoxyphenyl)-N,N-dimethylacetamide

(6-iodo-3-methoxy)phenyl-N,N-dimethylacetamide

Downstream raw materials:

2-(2-((2,6-dichlorophenyl)amino)-5-hydroxyphenyl)acetic acid

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