Methyl 3-[(4-Hydroxyphenyl)aMino]propanoate

Base Information

• Chemical Name: Methyl 3-[(4-Hydroxyphenyl)aMino]propanoate
• CAS No.: 70156-40-0
• Molecular Formula: C10H13NO3
• Molecular Weight: 195.218
• Hs Code.: 2922500090
• Mol file: 70156-40-0.mol

Synonyms:Methyl 3-[(4-Hydroxyphenyl)aMino]propanoate

Chemical Property of Methyl 3-[(4-Hydroxyphenyl)aMino]propanoate

Chemical Property:

• Melting Point: 93.5 °C
• Boiling Point: 374.8±27.0 °C(Predicted)
• PKA: 10.85±0.26(Predicted)
• PSA: 58.56000
• Density: 1.217±0.06 g/cm3(Predicted)
• LogP: 1.44020

Purity/Quality:

99% ^*data from raw suppliers

Methyl3-[(4-Hydroxyphenyl)amino]propanoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 3-[(4-Hydroxyphenyl)aMino]propanoate

There total 2 articles about Methyl 3-[(4-Hydroxyphenyl)aMino]propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

4-amino-phenol (123-30-8) + acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) → dimethyl 3,3'-(4-hydroxyphenylazanediyl)dipropanoate (70156-42-2) + N-(4-hydroxyphenyl)-β-alanine methyl ester (70156-40-0)

Guidance literature:

In water; at 50 ℃; for 24h;

DOI:10.1039/c0cc02502j

Reference yield: 51.0%

4-amino-phenol (123-30-8) + acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) → N-(4-hydroxyphenyl)-β-alanine methyl ester (70156-40-0)

Guidance literature:

With hydroquinone; In acetic acid; isopropyl alcohol; for 7h; Heating;

DOI:10.1007/BF00503202

Reference yield: 81.0%

potassium thioacyanate (333-20-0) + N-(4-hydroxyphenyl)-β-alanine methyl ester (70156-40-0) → 1-(4-hydroxyphenyl)-2-thio-5,6-dihydrouracil (84439-95-2)

Guidance literature:

With hydrogenchloride; acetic acid; at 120 ℃; 1)AcOH,120deg C, 18h 2)conc.HCl, reflux 1h;

DOI:10.1007/BF00503202

upstream raw materials:

4-amino-phenol

acrylic acid methyl ester

Downstream raw materials:

1-(4-hydroxyphenyl)-2-thio-5,6-dihydrouracil

N-(4-hydroxyphenyl)-β-alanine hydrazide

N-(4-hydroxyphenyl)-β-alanine

1-(4-hydroxyphenyl)dihydropyrimidine-2,4(1H,3H)-dione

Refernces

• 1、 Phippen, Christopher B. W.,Beattie, James K.,McErlean, Christopher S. P.. ""On-water" conjugate additions of anilines". supporting information; experimental part. p. 8234 - 8236. Retrieved 2010/12/20.