(R)-Methyl 4-aMino-2-((tert-butoxycarbonyl)aMino)-4-oxobutanoate

Base Information

• Chemical Name: (R)-Methyl 4-aMino-2-((tert-butoxycarbonyl)aMino)-4-oxobutanoate
• CAS No.: 124842-28-0
• Molecular Formula: C₁₀H₁₈N₂O₅
• Molecular Weight: 246.263
• Mol file: 124842-28-0.mol

Synonyms:(R)-Methyl 4-aMino-2-((tert-butoxycarbonyl)aMino)-4-oxobutanoate;Methyl N2-(tert-butoxycarbonyl)-D-asparaginate;Methyl (2S)-2-((tert-butoxycarbonyl)amino)-3-carbamoylpropanoate

Chemical Property of (R)-Methyl 4-aMino-2-((tert-butoxycarbonyl)aMino)-4-oxobutanoate

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 447.189°C at 760 mmHg
• PKA: 10.91±0.46(Predicted)
• Flash Point: 224.252°C
• PSA: 112.20000
• Density: 1.169g/cm³
• LogP: 1.28220
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98% ^*data from raw suppliers

METHYL-(2S)-2-((TERT-BUTOXYCARBONYL)AMINO)-3-CARBAMOYLPROPANOATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-Methyl 4-aMino-2-((tert-butoxycarbonyl)aMino)-4-oxobutanoate

There total 3 articles about (R)-Methyl 4-aMino-2-((tert-butoxycarbonyl)aMino)-4-oxobutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

N-tert-butyloxycarbonylasparagine (7536-55-2) + diazomethyl-trimethyl-silane (18107-18-1) → Nα-(tert-butoxycarbonyl)-(S)-asparagine methyl ester (124842-28-0)

Guidance literature:

In methanol; hexane; dichloromethane; at 0 ℃; for 0.5h;

DOI:10.1016/S0040-4039(02)00182-X

Reference yield: 94.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + N-tert-butyloxycarbonylasparagine (7536-55-2) → Nα-(tert-butoxycarbonyl)-(S)-asparagine methyl ester (124842-28-0)

Guidance literature:

In diethyl ether;

DOI:10.1016/S0960-894X(03)00083-0

Reference yield: 77.0%

methanol (67-56-1) + N-tert-butyloxycarbonylasparagine (7536-55-2) → Nα-(tert-butoxycarbonyl)-(S)-asparagine methyl ester (124842-28-0)

Guidance literature:

With ammonium cerium(IV) nitrate; at 25 ℃;

DOI:10.1016/j.tetlet.2004.01.136

upstream raw materials:

diazomethane

N-tert-butyloxycarbonylasparagine

diazomethyl-trimethyl-silane

methanol

Downstream raw materials:

L-t-Boc-Asnol

(S)-methyl 3-amino-2-((tert-butoxycarbonyl)amino)propanoate

2-tert-butoxycarbonylamino-3-[3-(4-nitro-phenyl)-ureido]-propionic acid methyl ester

N^α,N^α-bis(tert-butoxycarbonyl)-N-benzyl-(S)-asparagine methyl ester