L-ASPARAGINE METHYL ESTER HYDROCHLORIDE

Base Information

• Chemical Name: L-ASPARAGINE METHYL ESTER HYDROCHLORIDE
• CAS No.: 6384-09-4
• Molecular Formula: C₅H₁₀N₂O₃
• Molecular Weight: 146.146
• Mol file: 6384-09-4.mol

Synonyms:L-ASPARAGINE METHYL ESTER HYDROCHLORIDE

Chemical Property of L-ASPARAGINE METHYL ESTER HYDROCHLORIDE

Chemical Property:

• Melting Point: -58oC
• Boiling Point: 63.9oC at 760 mm Hg
• PSA: 96.40000
• LogP: 1.01410

Purity/Quality:

98% ^*data from raw suppliers

H-Asn-OMe 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of L-ASPARAGINE METHYL ESTER HYDROCHLORIDE

There total 3 articles about L-ASPARAGINE METHYL ESTER HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

methanol (67-56-1) + N-tert-butyloxycarbonylasparagine (7536-55-2) → methyl (S)-2,4-diamino-4-oxobutanoate (6384-09-4,108258-31-7,119991-47-8)

Guidance literature:

With ammonium cerium(IV) nitrate; Heating;

DOI:10.1016/j.tetlet.2004.01.136

Reference yield: 76.0%

N-(benzyloxycarbonyl)asparagine methyl ester (4668-37-5) → methyl (S)-2,4-diamino-4-oxobutanoate (6384-09-4,108258-31-7,119991-47-8)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; for 4h;

Reference yield:

Nα-(tert-butoxycarbonyl)-(S)-asparagine methyl ester (124842-28-0) → methyl (S)-2,4-diamino-4-oxobutanoate (6384-09-4,108258-31-7,119991-47-8)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃;

upstream raw materials:

N-(benzyloxycarbonyl)asparagine methyl ester

methanol

N-tert-butyloxycarbonylasparagine

N^α-(tert-butoxycarbonyl)-(S)-asparagine methyl ester

Downstream raw materials:

(6S,9S,15S)-methyl 15-(2-amino-2-oxoethyl)-6,9-dibenzyl-2,2-dimethyl-4,7,10,13-tetraoxo-3-oxa-5,8,11,14-tetraazahexadecan-16-oate

Refernces

• 1、 -. "ETHER COMPOUNDS AND USES THEREOF". Paragraph 0235. . Retrieved 2019/03/12.
• 2、 Howes, Colin,Alcock, Nathaniel W.,Golding, Bernard T.,McCabe, Richard W.. "Cyclo-(L-asparagyl-L-asparagyl) : Preparation and Crystal Structure". . p. 2287 - 2291. Retrieved 2007/10/02.