2-AMINO-2-(3-(TRIFLUOROMETHYL)PHENYL)ACETIC ACID HYDROCHLORIDE

Base Information

• Chemical Name: 2-AMINO-2-(3-(TRIFLUOROMETHYL)PHENYL)ACETIC ACID HYDROCHLORIDE
• CAS No.: 1134915-25-5
• Molecular Formula: C9H9ClF3NO2
• Molecular Weight: 255.624
• Mol file: 1134915-25-5.mol

Synonyms:2-AMINO-2-(3-(TRIFLUOROMETHYL)PHENYL)ACETIC ACID HYDROCHLORIDE;AMINO[3-(TRIFLUOROMETHYL)PHENYL]ACETIC ACID HYDROCHLORIDE

Chemical Property of 2-AMINO-2-(3-(TRIFLUOROMETHYL)PHENYL)ACETIC ACID HYDROCHLORIDE

Chemical Property:

• PSA: 63.32000
• LogP: 3.29210
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

2-Amino-2-(3-(trifluoromethyl)phenyl)aceticacidhydrochloride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-AMINO-2-(3-(TRIFLUOROMETHYL)PHENYL)ACETIC ACID HYDROCHLORIDE

There total 2 articles about 2-AMINO-2-(3-(TRIFLUOROMETHYL)PHENYL)ACETIC ACID HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-{[(tert-butoxy)carbonyl]amino}-2-[3-(trifluoromethyl)phenyl]acetic acid (146621-92-3) → 2-amino-2-(3-(trifluoromethyl)phenyl)acetic acid hydrochloride (1134915-25-5)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃;

Reference yield:

3-(TRIFLUOROMETHYL)BENZYLAMINE (2740-83-2) + acetic acid (64-19-7,77671-22-8) → 2-amino-2-(3-(trifluoromethyl)phenyl)acetic acid hydrochloride (1134915-25-5)

Guidance literature:

With hydrogenchloride; In water; at 110 ℃; under 6000.6 Torr;

DOI:10.1002/ejoc.201500300

Reference yield: 28.0%

2-amino-2-(3-(trifluoromethyl)phenyl)acetic acid hydrochloride (1134915-25-5) + benzyl bromide (100-39-0) → 2-(Dibenzylamino)-2-[3-(trifluoromethyl)phenyl]ethanol (1245622-89-2)

Guidance literature:

2-amino-2-(3-(trifluoromethyl)phenyl)acetic acid hydrochloride; benzyl bromide; With potassium carbonate; In ethanol; water; Reflux;

With lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether; Inert atmosphere; Cooling with ice bath; Reflux;

With water; In tetrahydrofuran; diethyl ether;

upstream raw materials:

2-{[(tert-butoxy)carbonyl]amino}-2-[3-(trifluoromethyl)phenyl]acetic acid

3-(TRIFLUOROMETHYL)BENZYLAMINE

acetic acid

Downstream raw materials:

C₂₃H₂₀F₃NO₂

C₂₅H₂₄F₃NO₂

C₃₀H₂₆F₃NO₂

2-(Dibenzylamino)-2-[3-(trifluoromethyl)phenyl]ethanol

Refernces

• 1、 -. "SUBSTITUTED 2-ACETAMIDO-5-ARYL-1,2,4-TRIAZOLONES AND USE THEREOF". Page/Page column 44. . Retrieved 2010/11/03.