4-Chloro-7-(phenylsulfonyl)-7H-pyrrolo-[2,3-d]pyrimidine-6-carboxylic acid

Base Information

Chemical Name:4-Chloro-7-(phenylsulfonyl)-7H-pyrrolo-[2,3-d]pyrimidine-6-carboxylic acid
CAS No.:1346447-16-2
Molecular Formula:C13H8ClN3O4S
Molecular Weight:337.743
Hs Code.:
Mol file:1346447-16-2.mol

Synonyms:4-Chloro-7-(phenylsulfonyl)-7H-pyrrolo-[2,3-d]pyrimidine-6-carboxylic acid

Suppliers and Price of 4-Chloro-7-(phenylsulfonyl)-7H-pyrrolo-[2,3-d]pyrimidine-6-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 6 raw suppliers

Chemical Property of 4-Chloro-7-(phenylsulfonyl)-7H-pyrrolo-[2,3-d]pyrimidine-6-carboxylic acid

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

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Technology Process of 4-Chloro-7-(phenylsulfonyl)-7H-pyrrolo-[2,3-d]pyrimidine-6-carboxylic acid

There total 2 articles about 4-Chloro-7-(phenylsulfonyl)-7H-pyrrolo-[2,3-d]pyrimidine-6-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 124-38-9,18923-20-1
carbon dioxide

: 186519-89-1
7-(benzenesulfonyl)-4-chloro-7H-pyrrolo[2,3-d]pyrimidine

: 1346447-16-2
4-chloro-7-(phenylsulfonyl)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid

Guidance literature:: 7-(benzenesulfonyl)-4-chloro-7H-pyrrolo[2,3-d]pyrimidine; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 4h; Inert atmosphere;

carbon dioxide; In tetrahydrofuran; hexane; at -78 - 20 ℃; Inert atmosphere;

With hydrogenchloride; In water; Inert atmosphere;
DOI:10.1016/j.bmc.2011.11.023

Reference yield:

: 98-09-9
benzenesulfonyl chloride

: 1346447-16-2
4-chloro-7-(phenylsulfonyl)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran / 0 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; hexane / 4 h / -78 °C / Inert atmosphere

2.2: -78 - 20 °C / Inert atmosphere

2.3: Inert atmosphere

With n-butyllithium; sodium hydride; In tetrahydrofuran; hexane;
DOI:10.1016/j.bmc.2011.11.023