2-(chloroMethyl)-3,5-difluoropyridine

Base Information

• Chemical Name: 2-(chloroMethyl)-3,5-difluoropyridine
• CAS No.: 1222633-85-3
• Molecular Formula: C6H4ClF2N
• Molecular Weight: 163.5524664
• Mol file: 1222633-85-3.mol

Synonyms:2-(chloroMethyl)-3,5-difluoropyridine

Chemical Property of 2-(chloroMethyl)-3,5-difluoropyridine

Chemical Property:

• Boiling Point: 158.2±35.0 °C(Predicted)
• PKA: -1.15±0.32(Predicted)
• PSA: 12.89000
• Density: 1.377±0.06 g/cm3(Predicted)
• LogP: 2.09860
• Storage Temp.: 2-8°C

Purity/Quality:

NLT 98% ^*data from raw suppliers

2-Chloromethyl-3,5-difluoropyridine 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(chloroMethyl)-3,5-difluoropyridine

There total 7 articles about 2-(chloroMethyl)-3,5-difluoropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

(3,5-difluoro-pyridin-2-yl)-methanol (1065267-14-2) → 2-(chloromethyl)-3,5-difluoropyridine (1222633-85-3)

Guidance literature:

With thionyl chloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; for 1h; Cooling with ice;

Reference yield:

3,5-difluoropyridine-2-carboxylic acid (745784-04-7) → 2-(chloromethyl)-3,5-difluoropyridine (1222633-85-3)

Guidance literature:

Multi-step reaction with 3 steps

1: thionyl chloride / 3 h / 60 °C / Cooling with ice

2: sodium tetrahydroborate / ethanol / 2 h / 0 - 20 °C / Cooling with ice

3: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C / Cooling with ice

With sodium tetrahydroborate; thionyl chloride; N,N-dimethyl-formamide; In ethanol; dichloromethane;

Reference yield:

3,5-difluoro-pyridine-2-carboxylic acid ethyl ester (1065267-10-8) → 2-(chloromethyl)-3,5-difluoropyridine (1222633-85-3)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tetrahydroborate / ethanol / 2 h / 0 - 20 °C / Cooling with ice

2: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C / Cooling with ice

With sodium tetrahydroborate; thionyl chloride; N,N-dimethyl-formamide; In ethanol; dichloromethane;

upstream raw materials:

3,5-difluoro-pyridine-2-carboxylic acid ethyl ester

3,5-difluoropyridine-2-carboxylic acid

(3,5-difluoro-pyridin-2-yl)-methanol

methyl 3,5-difluoropyridine-2-carboxylate

Downstream raw materials:

5-chloro-6-((3,5-difluoropyridin-2-yl)methoxy)-3-(5-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-2-methylphenyl)-2-methylpyrimidin-4(3H)-one

Refernces

• 1、 -. "PYRIDO[2,3-d]PYRIMIDIN-4-ONE COMPOUNDS AS TANKYRASE INHIBITORS". . . Retrieved 2015/05/26.
• 2、 -. "SUBSTITUTED PYRIMIDINONE-PHENYL-PYRIMIDINYL COMPOUNDS". . . Retrieved 2013/06/26.