METHYL 3,5-DIFLUOROPYRIDINE-2-CARBOXYLATE

Base Information

• Chemical Name: METHYL 3,5-DIFLUOROPYRIDINE-2-CARBOXYLATE
• CAS No.: 955885-64-0
• Molecular Formula: C7H5F2NO2
• Molecular Weight: 173.119
• Hs Code.: 2933399090
• Mol file: 955885-64-0.mol

Synonyms:METHYL 3,5-DIFLUOROPYRIDINE-2-CARBOXYLATE;5-difluoropyridine-2-carboxylate;Methyl 3,5-difluoropicolinate, 3,5-Difluoro-2-(methoxycarbonyl)pyridine;Methyl 3,5-difluoropicolinate

Chemical Property of METHYL 3,5-DIFLUOROPYRIDINE-2-CARBOXYLATE

Chemical Property:

• Vapor Pressure: 0.182mmHg at 25°C
• Boiling Point: 211.4°C at 760 mmHg
• PKA: -3.20±0.10(Predicted)
• Flash Point: 81.7°C
• PSA: 39.19000
• Density: 1.342g/cm³
• LogP: 1.14640
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99%+ ^*data from raw suppliers

Methyl3,5-Difluoropyridine-2-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL 3,5-DIFLUOROPYRIDINE-2-CARBOXYLATE

There total 5 articles about METHYL 3,5-DIFLUOROPYRIDINE-2-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

methanol (67-56-1) + 3,5-difluoropyridine-2-carboxylic acid (745784-04-7) → methyl 3,5-difluoropyridine-2-carboxylate (955885-64-0)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 - 20 ℃;

Reference yield: 64.0%

3-amino-5-fluoropyridine-2-carboxylic acid methyl ester (1052714-11-0) → methyl 3,5-difluoropyridine-2-carboxylate (955885-64-0)

Guidance literature:

With pyridine hydrogenfluoride; sodium nitrite; at 55 ℃; for 3h;

Reference yield:

3,5-difluoropyridine-2-carboxylic acid (745784-04-7) + diazomethyl-trimethyl-silane (18107-18-1) → methyl 3,5-difluoropyridine-2-carboxylate (955885-64-0)

Guidance literature:

In methanol; hexane; toluene; at 25 ℃; for 0.5h;

upstream raw materials:

methanol

3,5-difluoropyridine-2-carboxylic acid

diazomethyl-trimethyl-silane

3-amino-5-fluoropicolinonitrile

Downstream raw materials:

(3,5-difluoro-pyridin-2-yl)-methanol

2-(chloromethyl)-3,5-difluoropyridine