N-(2,3-dimethoxyphenyl)acetamide

Base Information

• Chemical Name: N-(2,3-dimethoxyphenyl)acetamide
• CAS No.: 121639-09-6
• Molecular Formula: C10H13NO3
• Molecular Weight: 195.218
• European Community (EC) Number: 675-298-4
• DSSTox Substance ID: DTXSID10374325
• Nikkaji Number: J1.341.792J
• Wikidata: Q82162862
• Mol file: 121639-09-6.mol

Synonyms:N-(2,3-dimethoxyphenyl)acetamide;121639-09-6;2,3-dimethoxyacetanilide;SCHEMBL6774791;DTXSID10374325;AKOS006293480;FS-4638;FT-0693617

Chemical Property of N-(2,3-dimethoxyphenyl)acetamide

Chemical Property:

• Melting Point: 81-83°C
• PSA: 47.56000
• LogP: 1.73520
• XLogP3: 1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 195.08954328
• Heavy Atom Count: 14
• Complexity: 196

Purity/Quality:

98%min ^*data from raw suppliers

N-(2,3-dimethoxyphenyl)acetamide 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)NC1=C(C(=CC=C1)OC)OC

Technology Process of N-(2,3-dimethoxyphenyl)acetamide

There total 4 articles about N-(2,3-dimethoxyphenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

2,3-dimethoxyaniline (6299-67-8) + acetyl chloride (75-36-5) → N-(2,3-dimethoxyphenyl)acetamide (121639-09-6)

Guidance literature:

With pyridine; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1016/j.tetlet.2017.01.075

Reference yield:

2,3-dimethoxybenzoic acid (1521-38-6) → N-(2,3-dimethoxyphenyl)acetamide (121639-09-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: thionyl chloride / benzene / 2 h / Heating

2.1: sodium azide / acetone; H₂O / 1 h / 15 °C

3.1: benzene / 2 h / 60 °C

3.2: conc. HCl / 18 h / 80 °C

4.1: triethylamine / CH₂Cl₂ / 1 h

With thionyl chloride; sodium azide; triethylamine; In dichloromethane; water; acetone; benzene;

DOI:10.1016/S0968-0896(01)00403-5

Reference yield:

2.3-Dimethoxybenzoylazid (56475-31-1) → N-(2,3-dimethoxyphenyl)acetamide (121639-09-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: benzene / 2 h / 60 °C

1.2: conc. HCl / 18 h / 80 °C

2.1: triethylamine / CH₂Cl₂ / 1 h

With triethylamine; In dichloromethane; benzene;

DOI:10.1016/S0968-0896(01)00403-5

upstream raw materials:

2,3-dimethoxyaniline

acetyl chloride

2,3-dimethoxybenzoic acid

2.3-Dimethoxybenzoylazid

Downstream raw materials:

2,3-dimethoxy-5,6-dinitro-aniline

acetic acid-(4-bromo-2,3-dimethoxy-anilide)

acetic acid-(2,3-dimethoxy-4,5-dinitro-anilide)

N-(2',3'-dimethoxyphenyl)-4-bromo-2,5-dimethylacetanilide