Curcumin β-D-Glucuronide

Base Information

• Chemical Name: Curcumin β-D-Glucuronide
• CAS No.: 227466-72-0
• Molecular Formula: C₂₇H₂₈O₁₂
• Molecular Weight: 544.512
• Hs Code.: 2938909090
• Mol file: 227466-72-0.mol

Synonyms:Curcumin β-D-Glucuronide;4-[(1E,6E)-7-(4-Hydroxy-3-Methoxyphenyl)-3,5-dioxo-1,6-heptadien-1-yl]-2-Methoxyphenyl β-D-Glucopyranosiduronic Acid;Curcumin-4-O-beta-D-glucuronide min. 85%

Chemical Property of Curcumin β-D-Glucuronide

Chemical Property:

• Boiling Point: 838.7±65.0 °C(Predicted)
• PKA: 2.78±0.70(Predicted)
• PSA: 189.28000
• Density: 1.470±0.06 g/cm3(Predicted)
• LogP: 0.93530

Purity/Quality:

99% ^*data from raw suppliers

Curcumin b-D-glucuronide sodium ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Curcumin β-D-Glucuronide is a metabolite of Curcumin (C838510) in hepatic tissue and portal blood.

Technology Process of Curcumin β-D-Glucuronide

There total 4 articles about Curcumin β-D-Glucuronide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

C34H36O15 → curcumin β-D-glucuronide (227466-72-0)

Guidance literature:

With water; sodium hydroxide; In methanol; at 50 ℃; for 1h; Cooling with ice;

Reference yield:

vanillin (121-33-5,8014-42-4) → curcumin β-D-glucuronide (227466-72-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: boron trioxide / ethyl acetate / 0.5 h / 80 °C

1.2: 0.5 h / 85 °C

2.1: boron trioxide / ethyl acetate / 0.5 h / 85 °C

2.2: 1 h / 85 °C

3.1: sodium hydroxide; water / methanol / 1 h / 50 °C / Cooling with ice

With water; sodium hydroxide; boron trioxide; In methanol; ethyl acetate;

Reference yield:

1-bromo-2,3,4-tri-O-acetyl-α-D-glucuronic acid methyl ester (21085-72-3) → curcumin β-D-glucuronide (227466-72-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: quinoline; silver(l) oxide / 2 h / 20 °C / Cooling with ice

2.1: boron trioxide / ethyl acetate / 0.5 h / 85 °C

2.2: 1 h / 85 °C

3.1: sodium hydroxide; water / methanol / 1 h / 50 °C / Cooling with ice

With quinoline; water; sodium hydroxide; silver(l) oxide; boron trioxide; In methanol; ethyl acetate;

upstream raw materials:

1-bromo-2,3,4-tri-O-acetyl-α-D-glucuronic acid methyl ester

acetylacetone

vanillin

Refernces