3-(4-AMinophenyl)-6,7-difluoroquinazoline- 2,4(1H,3H)-dione hydrochloride

Base Information

Chemical Name:3-(4-AMinophenyl)-6,7-difluoroquinazoline- 2,4(1H,3H)-dione hydrochloride
CAS No.:936500-99-1
Molecular Formula:C14H10ClF2N3O2
Molecular Weight:325.702
Hs Code.:
Mol file:936500-99-1.mol

Synonyms:3-(4-AMinophenyl)-6,7-difluoroquinazoline- 2,4(1H,3H)-dione hydrochloride;3-(4-AMinophenyl)-6,7-difluoro-2,4(1H,3H)-quinazolinedione hydrochloride (1:1);2,4(1H,3H)-Quinazolinedione, 3-(4-aminophenyl)-6,7-difluoro-, hydrochloride (1:1 )

Suppliers and Price of 3-(4-AMinophenyl)-6,7-difluoroquinazoline- 2,4(1H,3H)-dione hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of 3-(4-AMinophenyl)-6,7-difluoroquinazoline- 2,4(1H,3H)-dione hydrochloride

Chemical Property:

PSA：80.88000
LogP:2.92260

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 3-(4-AMinophenyl)-6,7-difluoroquinazoline- 2,4(1H,3H)-dione hydrochloride

There total 5 articles about 3-(4-AMinophenyl)-6,7-difluoroquinazoline- 2,4(1H,3H)-dione hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 936500-98-0
C₁₉H₁₇F₂N₃O₄

: 936500-99-1
C₁₄H₉F₂N₃O₂*ClH

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 - 30 ℃; for 5 - 6h; Product distribution / selectivity;

Reference yield:

: 207346-42-7
2-amino-4,5-difluoro-benzoic acid,methyl ester

: 936500-99-1
C₁₄H₉F₂N₃O₂*ClH

Guidance literature:: Multi-step reaction with 4 steps

1.1: dichloromethane / 3 h / 40 °C

2.1: triethylamine / tetrahydrofuran / 0.42 h

2.2: 2 h / 65 °C

3.1: methanol; sodium methylate / tetrahydrofuran / 4.33 h / 25 - 30 °C

4.1: hydrogenchloride / 1,4-dioxane / 5 - 6 h / 20 - 30 °C

With hydrogenchloride; methanol; sodium methylate; triethylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane;

Reference yield:

: C₉H₅F₂NO₃

: 936500-99-1
C₁₄H₉F₂N₃O₂*ClH

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / N,N-dimethyl-formamide / 20 °C

2: methanol; sodium methylate / tetrahydrofuran / 4.33 h / 25 - 30 °C

3: hydrogenchloride / 1,4-dioxane / 5 - 6 h / 20 - 30 °C

With hydrogenchloride; methanol; sodium methylate; triethylamine; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;