N-(cyclohexylmethyl)cyclohexanamine

Base Information

• Chemical Name: N-(cyclohexylmethyl)cyclohexanamine
• CAS No.: 87364-66-7
• Molecular Formula: C13H25N
• Molecular Weight: 195.348
• Hs Code.: 2921300090
• Mol file: 87364-66-7.mol

Synonyms:N-(cyclohexylmethyl)cyclohexanamine;UKRORGSYN-BB BBV-118555;N-(cyclohexylmethyl)cyclohexanamine(SALTDATA: HCl)

Chemical Property of N-(cyclohexylmethyl)cyclohexanamine

Chemical Property:

• Vapor Pressure: 0.00708mmHg at 25°C
• Boiling Point: 269.9°C at 760 mmHg
• Flash Point: 112.6°C
• PSA: 12.03000
• Density: 0.9g/cm³
• LogP: 3.87990

Purity/Quality:

95+% ^*data from raw suppliers

N-(CYCLOHEXYLMETHYL)CYCLOHEXANAMINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(cyclohexylmethyl)cyclohexanamine

There total 12 articles about N-(cyclohexylmethyl)cyclohexanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

N-cyclohexylcyclohexanecarboxamide (7474-36-4) → N-(Cyclohexylmethyl)-N-cyclohexylamine (87364-66-7) + N,1-dicyclohexylmethanimine dicyclohexyl imine (56037-75-3)

Guidance literature:

With triethyl borane; phenylsilane; potassium tert-butylate; In tetrahydrofuran; at 80 ℃; for 48h; chemoselective reaction; Inert atmosphere; Schlenk technique; Sealed tube;

DOI:10.1021/acs.joc.9b00277

Reference yield: 85.0%

cyclohexylamine (108-91-8,157973-60-9) + cyclohexanecarbaldehyde (2043-61-0) → N-(Cyclohexylmethyl)-N-cyclohexylamine (87364-66-7)

Guidance literature:

With borohydride exchange resin; triethylamine hydrochloride; In ethanol; for 1h; Ambient temperature;

DOI:10.1080/00397919308011255

Reference yield: 84.0%

Cyclohexyl iodide (626-62-0) + cyclohexylmethylamine (3218-02-8) → N-(Cyclohexylmethyl)-N-cyclohexylamine (87364-66-7)

Guidance literature:

With copper(l) iodide; tert-butylimino-tri(pyrrolidino)phosphorane; 1,1'-bi-2-naphthol; In N,N-dimethyl-formamide; acetonitrile; at -10 ℃; for 24h; Irradiation;

DOI:10.1021/jacs.7b09582

upstream raw materials:

N-Benzylaniline

N-phenyl(methylidene)cyclohexanamine

pimelaldehyde

cyclohexylamine

Downstream raw materials:

cyclohexanecarbaldehyde

6-[3-(N-Cyclohexyl-N-cyclohexylmethylaminocarbonyl)propoxy]carbostyril

Refernces

• 1、 Elliott, Daniel C.,Marti, Alex,Mauleón, Pablo,Pfaltz, Andreas. "H2 Activation by Non-Transition-Metal Systems: Hydrogenation of Aldimines and Ketimines with LiN(SiMe3)2". . p. 1918 - 1922. Retrieved 2019/01/16.
• 2、 Yao, Wubing,Fang, Huaquan,He, Qiaoxing,Peng, Dongjie,Liu, Guixia,Huang, Zheng. "A BEt3-Base Catalyst for Amide Reduction with Silane". supporting information. p. 6084 - 6093. Retrieved 2019/05/24.