4-Desmethoxypropoxyl-4-chloro Rabeprazole

Base Information

Chemical Name:4-Desmethoxypropoxyl-4-chloro Rabeprazole
CAS No.:168167-42-8
Molecular Formula:C₁₄H₁₂ClN₃OS
Molecular Weight:305.788
Hs Code.:2933997500
European Community (EC) Number:605-506-0
UNII:2YP19K112N
DSSTox Substance ID:DTXSID501158879
Wikidata:Q27255810
Mol file:168167-42-8.mol

Synonyms:168167-42-8;4-Desmethoxypropoxyl-4-chloro Rabeprazole;1H-Benzimidazole, 2-[[(4-chloro-3-methyl-2-pyridinyl)methyl]sulfinyl]-;2-[(4-chloro-3-methylpyridin-2-yl)methylsulfinyl]-1H-benzimidazole;2YP19K112N;2-[[(4-Chloro-3-methyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole;1H-Benzimidazole, 2-(((4-chloro-3-methyl-2-pyridinyl)methyl)sulfinyl)-;2-(((4-Chloro-3-methylpyridin-2-yl)methyl)sulfinyl)-1H-benzimidazole, (+/-)-;2-(((4-Chloro-3-methylpyridin-2-yl)methyl)sulfinyl)-1H-benzimidazole, (RS)-;2-((RS)-((4-Chloro-3-methylpyridin-2-yl)methyl)sulfinyl)-1H-benzimidazole;Lansoprazole impurity F [EP];UNII-2YP19K112N;2-[(RS)-[(4-Chloro-3-methylpyridin-2-yl)methyl]sulphinyl]-1H-benzimidazole;Lansoprazole EP Impurity F;SCHEMBL1268863;DTXSID501158879;BCP18295;AKOS030255497;4-Desmethoxypropoxyl-4-chloroRabeprazole;Rabeprazole/ Lansoprazole Chloro impurity;AC-30438;AS-78725;CS-0447797;FT-0666066;LANSOPRAZOLE IMPURITY F [EP IMPURITY];F19387;A1-04634;J-010434;RABEPRAZOLE SODIUM IMPURITY H [EP IMPURITY];Q27255810;Rabeprazole EP Impurity H;2-(((4-Chloro-3-methylpyridin-2-yl)methyl)sulfinyl)-1H-benzo[d]imidazole;(+/-)-2-(((4-chloro-3-methylpyridin-2-yl)methyl)sulfinyl)-1H-benzimidazole

Suppliers and Price of 4-Desmethoxypropoxyl-4-chloro Rabeprazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-Desmethoxypropoxyl-4-chloroRabeprazole
2.5mg
$ 180.00

Medical Isotopes, Inc.
4-Desmethoxypropoxyl-4-chloroRabeprazole
1 mg
$ 900.00

Biosynth Carbosynth
2-[[(4-Chloro-3-methyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole
25 mg
$ 2000.00

Biosynth Carbosynth
2-[[(4-Chloro-3-methyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole
5 mg
$ 550.00

Biosynth Carbosynth
2-[[(4-Chloro-3-methyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole
2 mg
$ 350.00

Biosynth Carbosynth
2-[[(4-Chloro-3-methyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole
1 mg
$ 200.00

Biosynth Carbosynth
2-[[(4-Chloro-3-methyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole
10 mg
$ 900.00

American Custom Chemicals Corporation
4-DESMETHOXYPROPOXYL-4-CHLORO RABEPRAZOLE 95.00%
1MG
$ 750.75

American Custom Chemicals Corporation
4-DESMETHOXYPROPOXYL-4-CHLORO RABEPRAZOLE 95.00%
10MG
$ 1963.50

A1 Biochem Labs
Rabeprazole/LansoprazoleChloroimpurity 95%
250 mg
$ 1600.00

Total 34 raw suppliers

Chemical Property of 4-Desmethoxypropoxyl-4-chloro Rabeprazole

Chemical Property:

Vapor Pressure:9.51E-13mmHg at 25°C
Melting Point:128-130°C
Boiling Point:564.1°C at 760 mmHg
PKA:9.56±0.10(Predicted)
Flash Point:295°C
PSA：77.85000
Density:1.5g/cm³
LogP:4.09320
Storage Temp.:-20°C Freezer
Solubility.:DMSO (Slightly), Methanol (Slightly, Heated, Sonicated)
XLogP3:2.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:305.0389609
Heavy Atom Count:20
Complexity:370

Purity/Quality:

99%, ^*data from raw suppliers

4-Desmethoxypropoxyl-4-chloroRabeprazole ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=C(C=CN=C1CS(=O)C2=NC3=CC=CC=C3N2)Cl
Uses A process impurity of Rabeprazole (R070500). 4-Desmethoxypropoxyl-4-chloro Rabeprazole (Rabeprazole EP Impurity H (Lansoprazole EP Impurity F)) is a process impurity of Rabeprazole (R070500).

Technology Process of 4-Desmethoxypropoxyl-4-chloro Rabeprazole

There total 8 articles about 4-Desmethoxypropoxyl-4-chloro Rabeprazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 103312-62-5
2-[(4-chloro-3-methylpyridin-2-yl)methylsulfanyl]-1H-benzoimidazole

: 168167-42-8
2-[(RS)-[(4-chloro-3-methylpyridin-2-yl)methyl]sulfinyl]-1H-benzimidazole

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at -15 - -10 ℃; for 1h;

Reference yield:

: 37699-43-7
2,3-dimethyl-4-nitropyridine N-oxide

: 1589-49-7
methoxypropanol

: 134469-07-1
Benzimidazol-2-thiol

: 168167-42-8
2-[(RS)-[(4-chloro-3-methylpyridin-2-yl)methyl]sulfinyl]-1H-benzimidazole

: 924663-38-7
2-[[(RS)-(1H-benzimidazol-2-yl)sulfinyl]methyl]-4-(3-methoxypropoxy)-3-methylpyridine 1-oxide

: 102804-77-3
2-[(RS)-[(4-methoxy-3-methylpyridin-2-yl)methyl]sulfinyl]-1H-benzimidazole

: 117976-89-3,177795-59-4
rabeprazole

Guidance literature:: Multistep reaction. Further byproducts given;

Reference yield:

: 59886-90-7
4-chloro-2,3-dimethylpyridine-N-oxide

: 168167-42-8
2-[(RS)-[(4-chloro-3-methylpyridin-2-yl)methyl]sulfinyl]-1H-benzimidazole

Guidance literature:: Multi-step reaction with 5 steps

1: 5 h / 120 °C

2: NaOH / H₂O / 1 h / 25 °C

3: 80 percent / SOCl₂ / CH₂Cl₂ / 2 h / 25 °C

4: 94 percent / NaOH / H₂O / 4 h / 25 °C

5: 60 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 1 h / -15 - -10 °C

With sodium hydroxide; thionyl chloride; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; water;